Sökning: "Tröger’s base"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Tröger’s base.

1. 1. Improving Tröger's Base Chemistry : Developing the Chemistry of Tröger's base

   Författare :Sami Dawaigher; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tröger’s base; Host Guest Chemistry; Metalation; Computational Chemistry; Supramolecular Chemistry;

   Sammanfattning : The Tröger’s base framework has been implemented in two different receptors. The first of these receptors, incorporating two 18-crown-6 moities, was used as a host in a binding study together with a sieries of bisammonium salts that yielded different binding constants that were then used as a benchmark to compare different computational methods (Molecular Mechanics (MM) and Density Functional Theory (DFT)) in predicting the correct results where the MM methods proved more effective. LÄS MER

3. 2. General Protocols for the Preparation of Tröger's Base Analogues and Molecular Recognition by Designed Tröger's Base Receptors

   Författare :Jacob Jensen; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; non-covalent bonds.; molecular recognition; desymmetrization; metal-mediated reactions; Tröger s base; synthetic protocols;

   Sammanfattning : 2,8-Dihalo substituted analogues of Tröger’s base were prepared via the Tröger’s base condensation reaction. These compounds were used as synthetic intermediates for the preparation of otherwise inaccessible functionalized Tröger’s base analogues. LÄS MER

4. 3. Synthesis and applications of analogues of Tröger's base as molecular tubes, receptor and ligands

   Författare :Anna Hansson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; bis-crown ether analogue; molecular recognition; molecular tubes; Tröger s base; dihalo-analogues;

   Sammanfattning : Tröger’s base was synthesized for the first time in 1887. The molecule is rigid, C2-symmetric and has a 90° angle, forming a chiral hydrophobic pocket. In this thesis, the synthesis of new analogues of Tröger’s base is described. 2- and 3-halo-substituted anilines have for the first time been condensed to Tröger’s base analogues. LÄS MER

5. 4. TRÖGER´S BASE AS SCAFFOLD FOR SYNTHETIC RECEPTORS

   Författare :Carlos Solano; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Organisk kemi; Organic chemistry; Makromolekylär kemi; Macromolecular chemistry; Molecular Recognition; Tröger´s base; Synthetic Receptors; Fysikalisk kemi;

   Sammanfattning : This work focuses on the use of the Tröger´s base as organic scaffold for the construction of synthetic receptors for different classes of organic molecules. The structural properties of the Tröger's base, i.e. chirality, rigidity and curvature, allow for synthetic modifications towards the recognition of different molecules. LÄS MER

7. 5. Making Analogues of Tröger's Base – Fused oligomers, endo/exo isomers and twisted amides

   Författare :Josep Artacho Ruiz; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The centenarian Tröger’s base (TB) was envisaged as scaffold for the construction of tubular-shaped cleft molecules due to its the remarkable structural properties. This endeavor started with the synthesis of the three possible diastereomers of a linear symmetrically fused tris-TB analogue, the anti-anti, the syn-syn, and the syn-anti. LÄS MER