Sökning: "Toxicology"

Visar resultat 6 - 10 av 384 avhandlingar innehållade ordet Toxicology.

1. 6. Setting occupational exposure limits : Practices and outcomes of toxicological risk assessment

   Författare :Linda Schenk; Christina Rudén; Alan Boobis; Michael Gilek; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Assessment Factor; DNEL; Euroepan Union; Occupational Exposure Limit; REACH; Risk Assessment; Regulatory Toxicology; SCOEL; Uncertainty Factor; Toxicology; Toxikologi;

   Sammanfattning : Occupational Exposure Limits (OELs) are used as an important regulatory instrument to protect workers’ health from adverse effects of chemical exposures. The main objective of this thesis is to study risk assessment practices in the setting of OEL in order to produce knowledge that will help improve the consistency and transparency of OELs. LÄS MER

3. 7. Direct and indirect mechanisms for aryl hydrocarbon receptor activation mediated by 6-formylindolo[3,2-b]carbazole

   Författare :Emma Wincent; Ulf Rannug; Agneta Rannug; Christopher Bradfield; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologisk genetik; Genetic Toxicology;

   Sammanfattning : The aryl hydrocarbon receptor (AhR) is mostly recognized for mediating the adverse effects of dioxins. In addition, endogenous activation of the AhR seems to have important biological functions.  Several studies have demonstrated an activation of the receptor when no exogenous ligand was added. LÄS MER

4. 8. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

   Författare :Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Sammanfattning : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. LÄS MER

5. 9. Pheromonal Mediated Behaviour and Endocrine Responses in Salmonids : The impact of Cypermethrin, Copper, and Glyphosate

   Författare :Alia Jaensson; Ingvar Brandt; Håkan Olsen; Kjell Döving; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cypermethrin; copper; glyphosate; behaviour; hormones; pheromones; olfaction; 11-ketotestosterone 11-KT ; 17α; 20β-dihydroxy-4-pregnen-3-one 17; 20β-P ; reproduction; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Sammanfattning : The effects of cypermethrin, copper and glyphosate on the endocrine system and subsequent response to female pheromones were investigated in mature male brown trout (Salmo trutta) parr.  Responses measured were the amount of strippable milt, blood plasma levels of both an androgen (11-ketotestosterone (11-KT)) and a progestin (17α,20β-dihydroxy-4-pregnen-3-one (17,20b-P)), and behavioural changes. LÄS MER

7. 10. Genetic Aspects of Environmental Disturbances in Marine Ecosystems : Studies of the Blue Mussel in the Baltic Sea

   Författare :Josefine Larsson; Mats Grahn; Inger Porsch-Hällström; Katarzyna Smolarz; Andrew Whitehead; Södertörns högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Blue mussel; Baltic Sea; anthropogenic disturbance; pollution; sewage effluents; harbors; genetics; genomics; Environmental Studies; Miljövetenskapliga studier; Östersjö- och Östeuropaforskning; Baltic and East European studies;

   Sammanfattning : Anthropogenic environmental changes can serve as drivers for evolutionary responses in wild populations. To predict the long-term impact of anthropogenic changes on populations, it is crucial to understand the genetic effects caused by these disturbances. LÄS MER