Sökning: "Torsten Unge"

Visar resultat 6 - 8 av 8 avhandlingar innehållade orden Torsten Unge.

  1. 6. Structure-Assisted Design of Drugs Towards HIV-1 and Malaria Targets : Applied on Reverse Transcriptase and Protease from HIV-1 and Plasmepsin II from Plasmodium falciparum

    Författare :Jimmy Lindberg; Torsten Unge; Alexander Wlodawer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; X-ray crystallography; Drug design; HIV-1; Malaria; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Globally of today, acquired immunodeficiency syndrome (AIDS) and malaria are two of the most threatening diseases known to mankind. The World Health Organization estimated that AIDS and malaria together claimed nearly 4 million lives in 2003 and many more were infected by the causative agent human immunodeficiency virus (HIV) and the Plasmodium falciparum (P. LÄS MER

  3. 7. Structural and Functional Studies of Ribose-5-phosphate isomerase B

    Författare :Annette K. Roos; Sherry L. Mowbray; Torsten Unge; Constance Jeffery; Uppsala universitet; []
    Nyckelord :Molecular biology; Mycobacterium tuberculosis; reaction mechanism; cis-enediolate high energy intermediate; allose-6-phosphate isomerase; rare sugar; pentose phosphate pathway; Rv2465c; X-ray crystallography; Molekylärbiologi;

    Sammanfattning : Ribose 5-phosphate isomerase (Rpi) is one of the major enzymes of the pentose phosphate pathway, where it catalyses the inter-conversion of ribose 5-phosphate (R5P) and ribulose 5-phosphate. Two forms of this isomerase with no significant amino acid sequence similarity exist, RpiA and RpiB. LÄS MER

  4. 8. Targeting Mycobacterium tuberculosis Proteins: Structure and Function Studies of Five Essential Proteins

    Författare :Adrian Suarez Covarrubias; Sherry Mowbray; Torsten Unge; Pedro Alzari; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; carbonic anhydrase; threonine synthase; FAS II; Rv0636; Rv1284; Rv1295; Rv3588c; Rv3778c; X-ray crystallography; Cell- och molekylärbiologi; Mycobacterium tuberculosis;

    Sammanfattning : This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal. LÄS MER