Sökning: "Torbjörn Gräslund"

Visar resultat 6 - 10 av 14 avhandlingar innehållade orden Torbjörn Gräslund.

  1. 6. Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins

    Författare :Hao Liu; Torbjörn Gräslund; Stefan Ståhl; Nick Devoogdt; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Targeted tumor therapy; immunotoxins; ADCs; affibody molecule; ADAPT; pseudomonas exotoxin A; maytansinoid; Bioteknologi; Biotechnology;

    Sammanfattning : Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. LÄS MER

  3. 7. Bioimaging for analysis of protein expression in cells and tissues using affinity reagents

    Författare :Emma Lundberg; Torbjörn Gräslund; Mathias Uhlén; Rainer Pepperkok; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Affibody; antibody; biomarker; cell line; cell microarray; colorectal cancer; confocal microscopy; HER2; immunohistochemistry; immunofluorescence; light microscopy; protein expression; protein localization; SATB2; tissue microarray; Bioengineering; Bioteknik; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The detection and analysis of biomolecules, such as proteins, are of great interest since these molecules are fundamental for life and our health. Due to the complexity of biological processes, there is a great advantage of studying proteins in their natural context, for example by using bioimaging. LÄS MER

  4. 8. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications

    Författare :Johan Seijsing; Torbjörn Gräslund; Uhlén Mathias; Inger Sandlie; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neonatal Fc receptor; FcRn; affibody molecule; immunoglobulin G IgG ; serum albumin SA ; albumin binding domain ABD ; half-life extension; blocking; autoimmune disease; pH-dependence; GAD67; GAD-1; gene therapy; Parkinson’s disease; zinc finger based artificial transcription factor; Biotechnology; Bioteknologi;

    Sammanfattning : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. LÄS MER

  5. 9. Affinity protein based inhibition of cancer related signaling pathways

    Författare :Erik Vernet; Torbjörn Gräslund; Antonino Cattaneo; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; Bioengineering; Bioteknik;

    Sammanfattning : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. LÄS MER

  7. 10. Analytical Approaches to Neurodegenerative Disease Protein Aggregation

    Författare :Henning Wiberg; Åsa Emmer; Torbjörn Gräslund; Leopold Ilag; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurodegenerative diseases; protein misfolding; protein aggregation; gel electrophoresis; isoelectric focusing; immunodetection; ELISA; immunoprecipitation; mass spectrometry; nanoelectrospray; liquid chromatography; neurodegenerativa sjukdomar; felveckade proteiner; proteinaggregering; geleektrofores; isoelektrisk fokusering; immundetektion; ELISA; immunoprecipitering; masspektrometri; nanoelektrospray; vätskekromatografi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : .... LÄS MER