Sökning: "Torbjörn Gräslund"
Visar resultat 11 - 14 av 14 avhandlingar innehållade orden Torbjörn Gräslund.
11. Spatial proteome profiling of the compartments of the human cell using an antibody-based approach
Sammanfattning : The human cell is complex, with countless processes ongoing in parallel in specialized compartments, the organelles. Cells can be studied in vitro by using immortalized cell lines that represent cells in vivo to a varying degree. LÄS MER
12. Engineering of alternative scaffold derived drug conjugates and fusion-toxins for targeted cancer therapy
Sammanfattning : Cancer is a major health problem, with premature death for many patients, and with a high monetary cost to society. The disease is complex to treat due to the many different types, but also because the disease-causing cells, that needs to be removed, are very similar to the normal cells. LÄS MER
13. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications
Sammanfattning : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. LÄS MER
14. Targeting Human Epidermal Growth Factor Receptors with Drug Conjugates Based on Affibody Molecules
Sammanfattning : Cancer is a major public health challenge and the second leading cause of death in the world, with millions of new cases being diagnosed each year. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy are many times effective, but may also cause damage to healthy cells, leading to side effects. LÄS MER
