Sökning: "Toll-like receptor 4"

Visar resultat 36 - 40 av 52 avhandlingar innehållade orden Toll-like receptor 4.

  1. 36. Studies on host-related pathogenesis of herpes simplex type-1 encephalitis in rat

    Författare :Biborka Bereczky-Veress; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In order to explore the molecular mechanisms of Herpes simplex encephalitis (HSE), a severe infection of the central nervous system (CNS) caused by Herpes simplex type 1 virus (HSV-1); a rat model resembling the human condition was characterized in the DA (Dark Agouti) strain. After injection into the whiskers’ area HSV-1 entered the CNS at the level of the brain stem via the trigeminal ganglion, subsequently spreading to the thalamus, cortex and olfactory bulb, leading to death at five days post infection (dpi). LÄS MER

  3. 37. A study on the role of genes of innate immunity in type 1 diabetes

    Författare :Saikiran K Sedimbi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic beta-cells. It is a polygenic disease in which maximal genetic susceptibility is conferred by the presence of MHC class II genes. LÄS MER

  4. 38. Nicotine and endotoxin in airway hyperreactivity and inflammation

    Författare :Yuan Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Active, as well as passive cigarette smoke exposure is detrimental to the human health, negatively affecting the cardiovascular, respiratory and immune systems. In addition, it is also carcinogenic. LÄS MER

  5. 39. Alpha1-Antitrypsin: New insights into the biological role in vitro and in vivo

    Författare :Izabela Nita; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Alpha1-Antitrypsin (AAT), an acute-phase glycoprotein produced predominantly in the liver by hepatocytes, but also by macrophages, pulmonary alveolar cells and intestinal epithelial cells, is a member of the SERPIN superfamily (SERine Protease INhibitors), and is one of the major inhibitors of neutrophil elastase in human plasma. Although AAT plays a critical role in regulating inflammation by inhibiting neutrophil serine proteases, recent studies suggest that AAT exhibits much broader anti-inflammatory activity. LÄS MER

  7. 40. Gene expression profiling in periodontitis

    Författare :Haleh Davanian Mohaghegh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The chronic inflammatory disease periodontitis is characterized by destruction of periodontal tissue, i.e. the tissues that surround and support the teeth. LÄS MER