Sökning: "Toll-like receptor 4"
Visar resultat 1 - 5 av 52 avhandlingar innehållade orden Toll-like receptor 4.
1. Airway hyperresponsiveness and viral recognizing toll-like receptors
Sammanfattning : Common colds caused by viruses are, in healthy individuals, usually self-limited and with relatively mild symptoms. In asthmatic individuals, respiratory viruses can burst the defense immune system and trigger asthma exacerbations, including causing airway hyperresponsiveness (AHR). LÄS MER
2. Renal failure in experimental sepsis : role of endothelin and the toll-like receptor 4
Sammanfattning : Sepsis is the leading cause of renal failure in critically ill patients, but the pathogenesis of septic kidney dysfunction is poorly defined. The current paradigm states that hypoperfusion and excessive renal vasoconstriction results in renal ischemia. LÄS MER
3. Effects of Inflammatory Mediators on Pulmonary Airways
Sammanfattning : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. LÄS MER
4. Platelets in inflammation : Role of complement protein C1q, C-reactive proteinand toll-like receptors
Sammanfattning : Platelets are proven essential in haemostasis, however, they are now also increasingly recognized as cells with important immunomodulatory properties, e.g. through interaction with leukocytes and several species of bacteria and by release inflammatory mediators upon activation. LÄS MER
5. Role of TLR4 in Escherichia coli urinary tract infection
Sammanfattning : In this thesis we have used P fimbriated E. coli as a model to investigate the mechanisms of bacterial recognition and cell activation by the urinary tract (UT) epithelium. We show that Toll like receptor 4 (TLR4) is crucial for the recognition and host response to P fimbriated E. coli. LÄS MER