Sökning: "Toll like receptor"

Visar resultat 6 - 10 av 107 avhandlingar innehållade orden Toll like receptor.

  1. 6. The role and mechanism of ubiquitin system in innate immune regulation

    Författare :Swarupa Panda; Nelson O. Gekara; Fredrik Elgh; Anna Överby; Geert van Loo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The ubiquitin system; Deubiquitinase; MYSM1; Innate immune regulation Toll-like receptor; RIG-l like receptors; Cytoplasmic DNA receptors; NOD-like receptors; Francisella tularensis; Immune subversion; molekylärbiologi; Molecular Biology;

    Sammanfattning : Pattern-recognition receptors (PRRs) include the cell surface or endosomal membrane localized Toll-like receptors (TLRs) and the cytoplasmic PRRs such as RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and cytoplasmic DNA receptors (CDRs). Triggering of PRRs culminates in the transcriptional induction of pro-inflammatory cytokines and type I interferons (IFNs) that coordinate protection against pathogens but require tight control to avert inflammatory diseases. LÄS MER

  3. 7. Renal failure in experimental sepsis : role of endothelin and the toll-like receptor 4

    Författare :Johan Fenhammar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sepsis is the leading cause of renal failure in critically ill patients, but the pathogenesis of septic kidney dysfunction is poorly defined. The current paradigm states that hypoperfusion and excessive renal vasoconstriction results in renal ischemia. LÄS MER

  4. 8. Effects of Inflammatory Mediators on Pulmonary Airways

    Författare :Ofir Bachar; Klinisk och experimentell allergiforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electric ?eld stimulation; bradykinin; airway; tumor necrosis factor a; Respiratory system; nitric oxide; Andningsorganen; Toll-like receptor; prostaglandin E2; neurotrophin; allergy;

    Sammanfattning : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. LÄS MER

  5. 9. Role of TLR4 in Escherichia coli urinary tract infection

    Författare :Patrik Samuelsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mykologi; virologi; mycology; Mikrobiologi; bakteriologi; serologi; transplantation; Microbiology; virology; bacteriology; Immunologi; serology; Immunology; Pathogen; Mucosa; P-fimbriae; Toll like receptor;

    Sammanfattning : In this thesis we have used P fimbriated E. coli as a model to investigate the mechanisms of bacterial recognition and cell activation by the urinary tract (UT) epithelium. We show that Toll like receptor 4 (TLR4) is crucial for the recognition and host response to P fimbriated E. coli. LÄS MER

  7. 10. Early-life gut microbiota and breast milk oligosaccharides in relation to childhood immune maturation and allergy

    Författare :Ylva Margareta Sjögren; Eva Sverremark-Ekström; Outi Vaarala; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; allergy; infant; gut microbiota; human milk oligosaccharides; Bifidobacterium; Lactobacillus; Bacteroides fragilis; Clostridium difficile; family size; secretory IgA; toll like receptor; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Atopic allergy is the most common chronic disease among children in the developed world. This high prevalence could be associated with low microbial exposure. The early gut microbiota appears to be important for immune maturation. LÄS MER