Sökning: "Tissue damage"

Visar resultat 1 - 5 av 552 avhandlingar innehållade orden Tissue damage.

1. 1. Computerized Cell and Tissue Analysis

   Författare :Azadeh Fakhrzadeh; Gunilla Borgefors; Cris Luengo Hendriks; Lena Holm; Nasir Rajpoot; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Image processing; Cell; Tissue; Segmentation; Classification; Histology; Computerized Image Processing; Datoriserad bildbehandling;

   Sammanfattning : The latest advances in digital cameras combined with powerful computer software enable us to store high-quality microscopy images of specimen. Studying hundreds of images manually is very time consuming and has the problem of human subjectivity and inconsistency. LÄS MER

3. 2. Improved dose response modeling for normal tissue damage and therapy optimization

   Författare :Magdalena Adamus-Górka; Bengt K. Lind; Anders Brahme; Panayiotis Mavroidis; Randall K. Ten Haken; Stockholms universitet; []
   Nyckelord :Normal tissue complications; radiobiological models; dose-response; volume effect; spinal cord; effective FSU size; medicinsk strålningsfysik; Medical Radiation Physics;

   Sammanfattning : The present thesis is focused on the development and application of dose response models for radiation therapy. Radiobiological models of tissue response to radiation are an integral part of the radiotherapeutic process and a powerful tool to optimize tumor control and minimize damage to healthy tissues for use in clinical trials. LÄS MER

4. 3. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

   Författare :Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

   Sammanfattning : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. LÄS MER

5. 4. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

   Författare :Martin Simonsson; Ingela Turesson; Gunilla Enblad; Dag Rune Olsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; dermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; gamma-H2AX; 53BP1; p21; checkpoint; apoptosis; mitosis; micro-RNA; miR-34a; Oncology; Onkologi; Oncology; Onkologi;

   Sammanfattning : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. LÄS MER

7. 5. Effects of Pulsed Electric Fields on Plant Tissue

   Författare :Yongyut Chalermchat; Livsmedelsteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Technological sciences; Electropermeabilization; Pulsed electric fields; Plant Tissue; Teknik;

   Sammanfattning : The interaction between biological cells and external electric fields has been of interest by scientists for several decades. Exposure of the cells to electric fields leads to various kinds of biophysical and biochemical responses. These responses can be used to characterize cell properties and/or to manipulate cell characteristics. LÄS MER