Sökning: "Thymus"

Visar resultat 11 - 15 av 97 avhandlingar innehållade ordet Thymus.

  1. 11. Immunomodulatory properties of steroid hormones

    Författare :Maria Taube; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DTH; oestradiol; corticosteroids; T cells; SCID mice; adoptive transfer; thymus; spleen.;

    Sammanfattning : Recent epidemiological, clinical and experimental evidence have suggested that steroid hormones play an important role in immune responses and in immune-mediated diseases. Many autoimmune diseases are treated with corticosteroids. LÄS MER

  3. 12. Immunohepatotoxicity of the persistent environmental pollutants perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)

    Författare :Mousumi Rahman Qazi; Joe DePierre; Christopher Lau; Stockholms universitet; []
    Nyckelord :Perfluorooctanoate; Perfluorooctane sulfonate; Peroxisome proliferator-activated receptor-alpha; Hepatomegaly; Immunotoxicity; Thymus; Spleen; Biochemistry; biokemi;

    Sammanfattning : Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), manufactured for a variety of industrial and consumer applications, are ubiquitous environmental pollutants. Their accumulation in humans and wildlife raises serious health concerns. Here, we examined the potential effects of PFOA and PFOS on the innate immune system in mice. LÄS MER

  4. 13. Early events in T cell development

    Författare :Karin Leandersson; Malmö Cancerimmunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; pTalpha; gammadelta T cell; alphabeta T cell; development; thymus; thymocyte; serology; transplantation; Immunologi; serologi;

    Sammanfattning : T cells constitute a heterogenous population of lymphocytes. Their unifying property is that they express surface bound antigen-receptors, called T cell receptors (TCRs). The TCR is a heterodimer composed of either TCRalpha and beta chain proteins (alphabeta TCR) or gamma and delta chain proteins (gammadelta TCR). LÄS MER

  5. 14. Aspects of T cell development contributing to autoimmunity

    Författare :Maria Carlsén; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTOC; T cell development; Type 1 diabetes; p53; Insulin; NOD; Negative selection; TGF-β; Tolerance; Thymus; Conditional cre lox knock out; Autoimmunity;

    Sammanfattning : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. LÄS MER

  7. 15. T Cell Ontogeny and Effector Functions in Galphai2-deficient Colitis

    Författare :Malin Bjursten; Göteborgs universitet; []
    Nyckelord :colitis; T cells; Galphai2- - mice; thymus; pro-inflammatory cytokines; alpha4 integrin;

    Sammanfattning : Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that affects millions of people worldwide, especially in northern countries such as Sweden, and is characterised by chronic uncontrolled inflammation of the intestinal mucosa. It is the general belief that multiple factors such as genetic and environmental aspects are involved in disease pathogenesis. LÄS MER