Sökning: "Thymic epithelial cells"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Thymic epithelial cells.

  1. 1. Thymic Stroma and T Cell Development. Impacts of Retinoic Acid Signaling

    Författare :Kerstin Wendland; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thymus; Thymic epithelial cells; Retinoic acid; T cell development; Stromal Cells;

    Sammanfattning : The development of functionally competent, self-tolerant T cells in the thymus is an essential prerequisite for the formation of adaptive immune responses against foreign pathogens. Thymic epithelial cells (TECs) form specialized stromal microenvironments in the cortex (cTEC) and medulla (mTEC) of the thymus that support all stages of T cell development, from the entry of thymocyte progenitors to the exit of mature naive T cells. LÄS MER

  3. 2. Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus

    Författare :Katarzyna Sitnik; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thymus; mesenchymal cells; retinoic acid; thymic epithelial cells;

    Sammanfattning : T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where bone marrow-derived progenitors migrate in a co-ordinated fashion through anatomically distinct cortical and medullary regions that are composed of epithelial and mesenchymal stromal elements. LÄS MER

  4. 3. On the regulation of immune responses to dietary and self antigens

    Författare :Susanne Lindgren; Göteborgs universitet; []
    Nyckelord :Tolerance; regulatory T cells; self antigens; oral tolerance; dietary antigens; intestinal epithelial cells; exosomes; Staphylococcus aureus enterotoxin A;

    Sammanfattning : Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible for the pathology seen in autoimmunity and allergy. Thymic-derived CD4+CD25+ regulatory T cells are indispensible for this regulation. We investigated if CD4+CD25+ Treg prevents auto-reactive responses in adult peripheral blood and cord blood. LÄS MER

  5. 4. Studies on 7a-hydroxycholesterol in extrahepatic tissues and cells

    Författare :Jie Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In human liver, primary bile acids are synthesized from cholesterol via the well-established neutral and also via the recently described acidic pathways. The latter includes 27-hydroxycholesterol 7alpha-hydroxylase. LÄS MER

  7. 5. Characteristics and functions of thymic exosomes in human and mouse

    Författare :Gabriel Skogberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exosome; thymus; tissue-restricted antigen; Aire; Down syndrome;

    Sammanfattning : Thymocytes develop in the thymus to become a functional pool of T-cells in the periphery. To achieve this, the thymocytes go through several steps of maturation and selection within the thymus. LÄS MER