Sökning: "Thrombin generation"

Visar resultat 21 - 25 av 50 avhandlingar innehållade orden Thrombin generation.

  1. 21. Studies of haemostasis in acute coronary syndromes and diabetes mellitus

    Författare :Mika Skeppholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pathophysiology of acute coronary syndromes (ACS) includes atherosclerotic plaque rupture and coronary thrombus formation. Antithrombotic treatment is effective but recurrent atherothrombotic or bleeding complications are not uncommon. LÄS MER

  3. 22. Cell derived microparticles : method development, and clinical and experimental studies

    Författare :Fariborz Mobarrez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cell derived microparticles (MP) are released from the cell membrane upon activation or apoptosis. They resemble their parent cell by exposing similar proteins or surface receptors. This enables identification of their cellular origin. LÄS MER

  4. 23. Determination of the overall haemostasis potential and fibrin gel permeability : method development and application in research and in clinical materials

    Författare :Aleksandra Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Global haemostatic assays; overall haemostasis potential; hypercoagulation; hypocoagulation; thrombophilia; haemophilia; fibrin gel porosity; LMMH therapy; acetylsalicylic acid therapy;

    Sammanfattning : We have previously developed a laboratory method that may screen the Overall Haemostasis Potential (OHP) in plasma based on spectophotometric measurement of an area under the fibrin aggregation curve in citrated plasma samples to which tiny amounts of exogenous thrombin and tissue-plasminogen activator (t-PA) are added. When the fibrin aggregation curve is created, the fibrinogen originally present in plasma is gradually converted to fibrin by the generated thrombin. LÄS MER

  5. 24. Experimental Aspects of Topical Haemostatic Agents

    Författare :Katarina Björses; Vaskulära sjukdomar - kliniska studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet stimulation; coagulation factors; experimental bleeding models; topical haemostatic agents;

    Sammanfattning : Control of haemorrhage is vital in all operative settings. As complement to traditional surgical haemostatic techniques, a heterogeneous collection of absorbable substances with haemostatic capacity have been developed; topical haemostatic agents. LÄS MER

  7. 25. Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition

    Författare :Masoud Razmara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus (DM) is associated with increased cardiovascular morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated mechanisms underlying hyperglycemia-induced platelet dysfunction, and its impact in DM patients. LÄS MER