Sökning: "Th1"
Visar resultat 11 - 15 av 259 avhandlingar innehållade ordet Th1.
11. Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
Sammanfattning : The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory G protein subunit Gαi2 spontaneously develop chronic colitis and have been used as a model for IBD, with particular similarities to UC. LÄS MER
12. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers
Sammanfattning : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. LÄS MER
13. Co-stimulation in gut mucosal immunity. Evidence of a differential regulationof local and systemic responses
Sammanfattning : In recent years we have learned that co-stimulatory factors are required as second signals for optimal T cell stimulation. Most types of immune responses are, therefore, dependent on the co-stimulatory signals that are provided by infection or immunization. LÄS MER
14. Functional analysis of intestinal dendritic cells
Sammanfattning : .... LÄS MER
15. Beyond Th1 and Treg : intestinal T helper cells in disease and tolerance
Sammanfattning : The human intestinal tract is not only one of the largest organs by surface area in our bodies but also harbors the greatest number of immune cells. These cells are crucial for maintaining tolerance towards the various food and microbial antigens and mounting protective inflammatory responses towards invading pathogens. LÄS MER