Sökning: "Telomere-Binding Proteins"

Hittade 5 avhandlingar innehållade orden Telomere-Binding Proteins.

  1. 1. Functional Studies of Telomere-Binding Proteins in Saccharomyces castellii

    Författare :Jenny Rhodin; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Rap1; DNA-binding domain; telomere evolution; Cdc13; telomerase; single-stranded overhang; telomere; yeast; Naumovia castellii; Saccharomyces castellii;

    Sammanfattning : Telomeres are the ends of linear eukaryotic chromosomes. The telomeres are essential for solving the end replication problem and they stabilize the genome by protection from degradation. The telomeres also protect the chromosomal ends from by being recognized as DNA breaks by the repair machinery, which could lead to end-to-end fusions. LÄS MER

  3. 2. The telomere binding proteins in yeast and their role in telomere maintenance

    Författare :Cecilia Gustafsson; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Telomeres are the end-structures of linear chromosome which are crucial for maintaining genome integrity. The telomeres prevent the DNA-repair machinery from recognizing the chromosome ends as double-strand breaks and from end-to-end fusions. LÄS MER

  4. 3. The maintenance of telomeres in the budding yeast Naumovozyma castellii

    Författare :Humberto Itriago; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Telomere; Telomere dynamics; Telomere-Binding Proteins; Cdc13; Rap1; RAD52; Rad51; Homologous recombination; ALT; Budding yeast; Naumovozyma castellii;

    Sammanfattning : Linear chromosomes of eukaryotic cells require the presence of functional nucleoprotein terminal structures, known as telomeres, to protect the integrity of the genome. The telomere is a highly dynamic and regulated structure constituted by short tandem DNA repeats rich in guanine nucleotides that extent as double-stranded DNA ending in a single-stranded 3′ overhang. LÄS MER

  5. 4. RAP1 at the Yeast Telomere

    Författare :Johan Wahlin; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytogenetik; DNA-binding; Saccharomyces; yeast; telomeric repeat; telomere; RAP1; repressor activator protein 1; Genetics; cytogenetics; Genetik;

    Sammanfattning : Telomeres are specialized complexes of DNA and proteins that cap and confer stability to the ends of eukaryotic chromosomes. The telomeric DNA of most eukaryotes is composed of tandemly arranged short repeats. Within the budding yeasts these repeats are diverged in length as well as in nucleotide composition. LÄS MER

  7. 5. Telomeres and telomerase and their functional applications in myeloproliferative neoplasms and acute myeloid leukemia

    Författare :Jenny Dahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myeloproliferative neoplasms (MPNs) are a group of diseases characterized by hyperproliferation in the myeloid lineages of the bone marrow, leading to increased levels of circulating mature blood cells from one or more lineages. MPNs consist of polycythemia vera, essential thrombocythemia and primary myelofibrosis. LÄS MER