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Hittade 2 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Integration of Transmembrane Helices into the Endoplasmic Reticulum

    Författare :Tara Hessa; Gunnar von Heijne; James Bowie; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : Membrane proteins reside in cell and organelle membranes. They play significant roles in many processes vital to living cells. Receptors and ion channels are examples of membrane proteins that regulate the physiological state of the cell and are attractive targets for drug development. LÄS MER

  2. 2. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum

    Författare :Theresa Kriegler; Tara Hessa; Patricia Clark; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Co-translational translocation; Xbp1 arrest peptide; Translocon-associated protein TRAP complex; Prion protein; Insulin; biokemi; Biochemistry;

    Sammanfattning : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). LÄS MER