Sökning: "Tamoxifen"

Visar resultat 21 - 25 av 99 avhandlingar innehållade ordet Tamoxifen.

  1. 21. Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer

    Författare :Anna-Maria Larsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Anemia; Hypoxia; Erythropoietin EPO ; EPO receptor EPOR ; Estrogen Receptor ER ; Hypoxia-Inducible Factors HIFs ; Tamoxifen Response; Proliferation;

    Sammanfattning : The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. LÄS MER

  3. 22. Sex, hormonal factors and pancreatic cancer

    Författare :Gustav Andersson; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; Sex; Anthropometry; Hormonal factors; Tamoxifen treatment;

    Sammanfattning : Pancreatic cancer represents three percent of all incident cancer cases in developed countries, but stands the 7th most common cause of cancer related death. Worldwide, pancreatic cancer is more common among men, however in Sweden, the incidence ratio between sexes is levelling. LÄS MER

  4. 23. CYP2D6-polymorphism and effect of adjuvant tamoxifen in breast cancer patients

    Författare :Linda Thorén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Adjuvant tamoxifen at the standard dose of 20 mg daily for five to ten years reduces the risk for relapse and mortality in hormone sensitive breast cancer. The effect however varies and no early marker of poor response is yet available. LÄS MER

  5. 24. The Akt/mTOR Pathway and Estrogen Receptor Phosphorylations : a crosstalk with potential to predict tamoxifen resistance in breast cancer

    Författare :Josefine Bostner; Olle Stål; Cecilia Bivik; Malin Sund; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Estrogen receptor α content is the primary breast cancer biomarker distinguishing the patients responsive from the non-responsive to endocrine treatments. Tamoxifen is an estrogen competitor with large potential to treat breast cancer patients and prolongs time to recurrence. LÄS MER

  7. 25. Effects of sex steroids and tamoxifen on VEGF in the breast

    Författare :Stina Garvin; Charlotta Dabrosin; Lars Holmgren; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; breast cancer; estradiol; MCF-7; microdialysis; nude mice; progesterone; sVEGFR-1; VEGFR-2; Oncology; Onkologi;

    Sammanfattning : Sex steroid exposure constitutes a risk factor for breast cancer, but little is known about the effects of sex steroids on factors mediating angiogenesis, the development of new blood vessels, in normal and malignant breast tissue. In this thesis we have investigated the effects of estradiol, progesterone, and the nonsteroidal anti-estrogen tamoxifen on vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and VEGFR-2) in normal human breast tissue, endothelial cells, and breast cancer. LÄS MER