Sökning: "TUNEL staining"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden TUNEL staining.

  1. 1. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER

  3. 2. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors

    Författare :Tina Kunz; Tadeusz Wieloch; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. LÄS MER

  4. 3. Prevention of Experimental Cataract Induced by UVR

    Författare :Martin Kronschläger; Per Söderberg; Madeleine Zetterberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cataract; ultraviolet radiation; apoptosis; thioltransferase; caffeine;

    Sammanfattning : Cataract is the leading cause of blindness in the world and is defined by opacification of the normally transparent lens of the eye. The major avoidable cause of cataract is ultraviolet radiation (UVR), but no current strategies have been developed to prevent the onset of cataract. LÄS MER

  5. 4. Immunocytochemical visualization of cathepsin D during oxidative stress

    Författare :Karin Roberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Cathepsin D is the major aspartic protease in lysosomes, and it is found in almost all animal cells. In the present studies, a pre-embedding immunocytochemical method was used to visualize cathepsin D in cultured cells. The protein can be detected at both light and electron microscopic levels by neutral-pH silver enhancement of ultrasmall (0. LÄS MER

  7. 5. Transurethral microwave thermotherapy of benign prostatic hyperplasia : mechanisms of action and clinical outcome

    Författare :Marianne Brehmer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :benign prostatic hyperplasia; transurethral microwave thermotherapy; clinical outcome; sham treatment; innervation; urethral sensitivity; necrosis; apoptosis; prostatic stromal cells in culture;

    Sammanfattning : Background: The therapeutic value of transurethral microwave thermotherapy (TUMT) in benign prostatic hyperplasia (BPH) is a matter of debate. Aims: Evaluation of the clinical effect of TUMT and of various duration of the treatment; investigation of the kind and extent of tissue lesions induced by TUMT and of the mechanisms behind the therapeutic effect; investigation of the effect of heat on human prostate stromal cells in cell culture. LÄS MER