Sökning: "TR[beta]- -"

Hittade 2 avhandlingar innehållade orden TR[beta]- -.

  1. 1. Adaptability of skeletal muscle to hormone treatment in relation to gender and aging

    Författare :Fushun Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :skinned muscle fiber; gender; aging; steroid hormone; V0 electrophoresis; MyHC; MyLC; enzymehistochemistry; hyperthyroid rat; thyroid hormone receptor TR deficient TR[alpha]1 - -; TR[beta]- -; and TR[alpha]1- -[beta]- - mice;

    Sammanfattning : The aims of this study were to investigate the expression of myosin isoforms, muscle contractility at the cell level, and changes in these parameters in response to altered hormonal status in aging male and female rodents. In addition, by using mice lacking thyroid hormone receptors (TR[alpha]1 or TR[beta] or TR[alpha]1/[beta]) we tried to improve our understanding of the mechanisms by which thyroid hormone regulates the expression of specific MyHC isoforms via these different nuclear receptors. LÄS MER

  3. 2. Physiological changes in mice deficient in different subtypes of thyroid hormone receptors : a focus on studies of heart and muscle

    Författare :Catarina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :heart rate; ECG; body temperature; [beta]-adrenergic receptor density; thyroid hormone; isometric twitch; SERCa;

    Sammanfattning : The aim of these studies was to determing the specific roles of the different subtypes of thyroid hormone receptors (TR), with focus on heart and muscle function, by using mice deficient in TR[alpha]1, TR[beta] (both TR[beta]1 and TR[beta]2 subtypes) and TR[alpha]1/[beta]. For this purpose, new techniques were set up to study various physiological parameters in these mice. LÄS MER