Sökning: "TP53"

Visar resultat 16 - 20 av 90 avhandlingar innehållade ordet TP53.

  1. 16. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer

    Författare :Angelos Heldin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. LÄS MER

  3. 17. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer

    Författare :Nicolai Arildsen; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovarian cancer; Molecular biology; genetic variant; TP53 mutation; early detection; Drug Screening Assays; Antitumor; bioinformatics; next generation sequencing; NGS; prognostic and predictive biomarkers; ovarian clear cell cancer; high-grade serous ovarian cancer;

    Sammanfattning : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. LÄS MER

  4. 18. HER2 and TP53 in human breast cancer : studies of methods and prognostic value

    Författare :Jenny Bergqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cancer; HER2; c-erbB-2; TP53; tamoxifen; endocrine resistance;

    Sammanfattning : Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. LÄS MER

  5. 19. Heritable TP53-related cancer syndrome in Sweden : characterisation of genotype-phenotype correlation and surveillance

    Författare :Meis Omran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Around 25% of all cancers are considered as familial and are caused by an inherited susceptibility to develop certain tumours. But only 5-10% are hereditary and caused by known high risk cancer genes associated with specific cancer risk syndromes. LÄS MER

  7. 20. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy

    Författare :Mireia Palomar Siles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. LÄS MER