Sökning: "TNF-inhibitors"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet TNF-inhibitors.

  1. 1. Real-Time Monitoring of Healthcare Interventions in Routine Care : Effectiveness and Safety of Newly Introduced Medicines

    Författare :Thomas Cars; Johan Sundström; Björn Wettermark; Martin Neovius; Til Stürmer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electronic Health Records; Comparative Effectiveness Research; Comparative Safety Research; Sequential drug monitoring; propensity score; real-world data; infliximab; TNF-inhibitors; dronedarone; amiodarone; flecainide; Farmakoepidemiologi; Pharmacoepidemiology;

    Sammanfattning : Before market authorization of new medicines, their efficacy and safety are evaluated using randomized controlled trials. While there is no doubt about the scientific value of randomized trials, they are usually conducted in selected populations with questionable generalizability to routine care. LÄS MER

  3. 2. Immunological mechanisms in systemic autoimmunity : autoantibodies and chemokines in systemic lupus erythematosus and during treatment with TNF inhibitors in rheumatoid arthritis

    Författare :Catharina Eriksson; Karl-Gösta Sundqvist; Solbritt Rantapää-Dahlqvist; Mari Norgren; Thomas Skogh; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; chemokines; T-cells; autoantibodies; CD91; Clinical immunology; Klinisk immunologi; Rheumatology; Reumatologi; Clinical Immunology; klinisk immunologi; reumatologi; rheumatology;

    Sammanfattning : Background. Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease that, without powerful treatment, may lead to irreversible joint damage. During the past decade, anti-cytokine therapy has become available, e.g. LÄS MER

  4. 3. Extra-articular Rheumatoid Arthritis Risk Factors and Consequences

    Författare :Britt-Marie Nyhall-Wahlin; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiographic progression; disease activity burden; smoking; rheumatoid nodules; Rheumatoid arthritis; extra-articular manifestations; TNF-inhibitor treatment;

    Sammanfattning : Rheumatoid arthritis (RA) is a systemic disease not only restricted to the joints, but can also be associated with the development of extra-articular manifestations. Extra-articular RA (ExRA) is of clinical importance because of the associated morbidity and increased risk of premature mortality compared with RA patients in general. LÄS MER

  5. 4. Biological therapy in rheumatoid arthritis : epidemiological studies

    Författare :Katerina Chatzidionysiou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The landscape of RA treatment has unquestionably changed dramatically during the last decade. A deeper understanding of the pathophysiological and immunological mechanisms in RA, earlier and more aggressive treatment, and the development and introduction to daily clinical practice of a new class of antirheumatic drugs, the so-called biologic therapies, has contributed to this ‘revolution’. LÄS MER

  7. 5. Epidemiological aspects of ankylosing spondylitis in Sweden. Characterization, prevalence and prognosis

    Författare :Sofia Exarchou; Internmedicin - epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Ankylosing Spondylitis (AS) is a chronic, potentially disabling, inflammatory disease that poses a longstanding burden on the patient and the society. The epidemiology of AS in Sweden has not been extensively studied previously. LÄS MER