Sökning: "TNF-alpha"

Visar resultat 21 - 25 av 165 avhandlingar innehållade ordet TNF-alpha.

  1. 21. Effect of Drugs on Rabbit Retina

    Författare :Anna Cardiakidis Myers; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug toxicity; electroretinography; histopathology; intravitreal injection; rifabutin; anti-VEGF; triamcinolone; benzyl alcohol; anti-TNF-alpha; adalimumab;

    Sammanfattning : The adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. LÄS MER

  3. 22. Cyclic Nucleotide Phosphodiesterase 3B: Regulation in rat adipocytes and 3T3-L1 cells

    Författare :Tova Landström; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3T3-L1 TNF-alpha; adipocyte; insulin; p70S6 kinase; mitogen-activated protein kinase; protein kinase B; phosphatidylinositol-3 kinase; phosphodiesterase 3B; cAMP; lipolysis; phosphorylation; signal transduction; Biochemistry; Metabolism; Biokemi; metabolism;

    Sammanfattning : Insulin stimulation of rat adipocytes results in phosphorylation and activation of the cyclic nucleotide phosphodiesterase 3B (PDE3B), a key enzyme in the antilipolytic signalling pathway of this hormone. In this thesis, the site phosphorylated in PDE3B upon stimulation of rat adipocytes with insulin and/or the beta-adrenergic agonist, isoproterenol is identified. LÄS MER

  4. 23. Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes

    Författare :Kristian Hallermalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor escape; cytotoxic lymphocytes; interferon-gamma; TNF-alpha; granzyme B; Perforin; Fas ligand;

    Sammanfattning : Today, ample evidence demonstrates a clear role for the immune system in the battle against cancer. However, the relatively high rate of mutation and proliferation of tumor cells, in combination with the selective pressure exerted by the immune system, can potentially lead to the generation of genetically altered tumor cells, which are able to evade recognition by the immune system and continue to grow and form tumors. LÄS MER

  5. 24. Studies on fat cell function in human obesity and insulin resistance

    Författare :Patrik Löfgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fat cell; lipolysis; lipogenesis; leptin; obesity; perilipin; polymorphism; post-obese; TNF-alpha; weightreduction.;

    Sammanfattning : Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks of common obesity in humans. It is, however, not known whether these aberrations are caused by obesity per se or is a consequence of obesity. LÄS MER

  7. 25. Tobacco smoking and periodontal disease : some clinical, microbiological and immunological aspects

    Författare :Lennart Boström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :gingival crevicular fluid; IL-1[beta]; IL-1ra; Il-6; periodontal bone height; periodontal surgery; periodontopathogens; TNF-[alpha]; smoking;

    Sammanfattning : The main aim of the thesis was to evaluate the influence of smoking on the inflammatory response in periodontal disease. The overall study population included 347 patients: 224 men and 123 women, aged between 31-86 years, with moderate to severe periodontal disease. LÄS MER