Sökning: "TLR4"

Visar resultat 11 - 15 av 85 avhandlingar innehållade ordet TLR4.

  1. 11. Dual cytokine inducing properties of HMGB1

    Författare :Hulda Hreggvidsdottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : High mobility group box protein 1 (HMGB1) is a nuclear protein that can be released either passively by necrotic cells or actively by stimulated cells. Extracellular HMGB1 is a potent inducer of inflammation and the importance of HMGB1 as a mediator in a number of inflammatory diseases including rheumatoid arthritis, sepsis and ischemia‐reperfusion injury, has been demonstrated by successfully targeting the protein in preclinical models. LÄS MER

  3. 12. Renal failure in experimental sepsis : role of endothelin and the toll-like receptor 4

    Författare :Johan Fenhammar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sepsis is the leading cause of renal failure in critically ill patients, but the pathogenesis of septic kidney dysfunction is poorly defined. The current paradigm states that hypoperfusion and excessive renal vasoconstriction results in renal ischemia. LÄS MER

  4. 13. S100A9 in inflammation

    Författare :Zhifei He; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; S100A9; inflammation; oxyclozanide; CD14;

    Sammanfattning : S100A9 is a small (13 kD) cytosolic calcium-binding protein. The protein is mainly expressed in neutrophils and monocytes in human but can also be expressed in other cell types under inflammatory conditions. S100A9 is normally co-expressed with S100A8 and forms S100A8/S100A9 heterodimers. LÄS MER

  5. 14. Gene regulation and immune mechanisms in multiple sclerosis experimental models

    Författare :Monica Sofia Calado Marta; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our strategy was to fine map and identify, in an unbiased way, genes or small regions that regulate myelin-oligodendrocyte glycoprotein-induced EAE (MOG-EAE). Such genes are important as they can then be tested for a role in MS. LÄS MER

  7. 15. Signaling and Adhesive Mechanisms in Acute Pancreatitis

    Författare :Darbaz Awla; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; trypsinogen activation; Acute pancreatitis; leukocyte recruitment and adhesion;

    Sammanfattning : Acute pancreatitis (AP) is an inflammatory disease with variable severity ranging from mild interstitial edematous to severe necrotizing disease. The overall mortality rate of AP is 8-9%. Specific treatment of AP is lacking which is partly related to an incomplete understanding of the basic pathophysiology behind the disease. LÄS MER