Sökning: "TIMP"

Visar resultat 16 - 20 av 55 avhandlingar innehållade ordet TIMP.

  1. 16. Matrix-degrading metalloproteinases and cytokines in multiple sclerosis and ischemic stroke

    Författare :Mathilde Cornelia Maria Kouwenhoven; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by blood-brain barrier breakdown, perivascular inflammation and demyelination. In ischemic stroke, an inflammatory reaction develops shortly after arterial occlusion. LÄS MER

  3. 17. Proteolytic imbalance in COPD : epidemiological and clinical aspects

    Författare :Robert Linder; Anders Blomberg; Anne Lindberg; Annelie F. Behndig; Arne Egesten; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Matrix metalloproteinases; MMP-9; MMP-12; lung function decline; epidemiology; COPD; OLIN; KOLIN; medicin; Medicine;

    Sammanfattning : Background: The complete pathologic mechanism behind the development of chronic obstructive pulmonary disease (COPD) remains unclear, but several risk factors have been identified, of which smoking is the most common. Proteolytic imbalance contributes to lung tissue degradation and is related to both smoking and COPD symptoms. LÄS MER

  4. 18. Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts

    Författare :Helena Domeij; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Matrix metalloproteinases; tissue inhibitor of metalloproteinases; gingival fibroblasts; monocytes; periodontal diseases;

    Sammanfattning : Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes collectively responsible for the metabolism of extra cellular matrix components. Disturbance of the physiological balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. LÄS MER

  5. 19. Inflammatory response in periodontal tissue in children with Down syndrome

    Författare :Georgios Tsilingaridis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Periodontal diseases are inflammatory diseases affecting the supporting tissues of the teeth. Subjects with Down syndrome have a higher prevalence of periodontal disease compared to healthy controls. Periodontal disease in Down syndrome is considered to be multifactorial, although the aetiology is uncertain. LÄS MER

  7. 20. Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility

    Författare :Anna Forslöw; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human immune system, which protects the body from invading pathogens, largely depends on the proper function of lymphocytes, which are highly motile and constantly recirculate the blood and lymph. Adhesive and motile capability is often amplified or uncontrolled during chronic inflammatory conditions such as autoimmune diseases. LÄS MER