Sökning: "TIMP"

Visar resultat 11 - 15 av 55 avhandlingar innehållade ordet TIMP.

  1. 11. Matrix metalloproteinases and their inhibitors in ocular neovascularization

    Författare :Björn Steén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis; Neovascularization; Retina; Bruch membrane; Cornea; MMP; TIMP; VEGF; In situ hybridization.;

    Sammanfattning : Growth of pathological new vessels (angiogenesis) in the eye is a leading cause of severe vision-loss. Ocular angiogenesis is seen in the anterior part of the eye as in corneal neovascularization, or in the posterior part as in diabetic retinopathy, retinopathy of prematurity or age-related macular degeneration. LÄS MER

  3. 12. Urinary tract infection and renal scarring

    Författare :Milan Chromek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :urinary tract infection; renal scarring; cathelicidin; LL-3 7; NIMP-9; TIMP-1;

    Sammanfattning : Urinary tract infection (UTI) is the most common bacterial infection. Although most patients with UTI have a good prognosis, there is a risk of serious complications in a group of them. LÄS MER

  4. 13. Colorectal cancer treatment and early response evaluation : how do we best evaluate treatment response?

    Författare :Per Byström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Colorectal cancer; TIMP-1; tumor marker; PET; CEA; CA19-9; TPA; SAA; CRP; prealbumin; HRQoL;

    Sammanfattning : Colorectal cancer (CRC) is common, being responsible for around 12% of new cancers in Sweden, and contributing heavily to the large numbers of cancer deaths yearly. CRC is the second most common cause of cancer death not only in Sweden but also worldwide. LÄS MER

  5. 14. Choroidal neovascularization (CNV) : clinical and experimental aspects

    Författare :Lennart Berglin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CNV; angiogenesis; age-related macular degeneration; AMD; aging; surgery; endothelial cells; VEGF; MMP; TIMP; MMP-2; immunohistochemistry; ECM; RPE; Bruch s membrane; wound healing; inflammation; macrophages; in-situ hybridization; mRNA; immature vessels; MMP-9; TIMP- 3; MMP-2 deficiency;

    Sammanfattning : This work comprises different aspects of choroidal neovacularization (CNV); a leading cause of visual loss in the aged. It is an example of angiogenesis and a complication of age-related macular degeneration (AMD) The purpose was to study if patient age influences outcome of CNV surgery, to characterize the cellular content of CNV, to analyze the expression of vascular endothelial growth factor (VEGF) and various matrix metalloproteinases (MMP) and their inhibitors (TIMP) in CNV and to study if MMP-2 influences experimental CNV growth. LÄS MER

  7. 15. Genomic clues to secondary injury mechanisms in brain trauma

    Författare :Christina von Gertten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :traumatic brain injury; cerebral cortical contusion; weight-drop model; depolarisation; gene expression; nestin; MMP-9; TIMP-1; osteopontin; CD44; hippocalcin; NMDA receptor; microarray; rat;

    Sammanfattning : Traumatic brain injury (TBI) is a heterogenous disease that can lead to persistent disability or death. The immediate mechanical disruption of brain tissue is followed by a phase of secondary brain injury. During this phase TBI challenges clinical interventions due to its complexity. LÄS MER