Sökning: "TIF-2"

Hittade 3 avhandlingar innehållade ordet TIF-2.

  1. 1. Molecular mechanisms of estrogen and antiestrogen action

    Författare :Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER

  3. 2. Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex

    Författare :Petra Berg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The AhR belongs to the bHLH/PAS family of transcription factors, which mediates biological effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand the AhR is located in the cytoplasmatic compartment of the cell associated with the molecular chaperone Hsp90, p23 and a member of the immunophilin family of proteins, XAP-2. LÄS MER

  4. 3. Transcription factors involved in negative and positive gene regulation by glucocorticoids

    Författare :Nanthakumar Subramaniam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Steroid hormones, including glucocorticoids (GCs), control a wide variety of developmental and physiological responses in higher eukaryotic organisms. They pass through the plasma membrane and bind to specific receptor proteins inside the cell. LÄS MER