Sökning: "THP-1"
Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet THP-1.
1. Vaginal commensal bacteria. Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI
Sammanfattning : Vaginal commensal bacteria Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI Louise Strömbeck Department of Infectious Medicine, Gothenburg University Abstract Lactobacillus is the predominant species of the vaginal microbiota in women of childbearing age. Lactobacilli are thought to contribute to the local immune defence by producing a variety of antimicrobial substances and, thereby, attenuate growth of other opportunistic bacteria. LÄS MER
2. Endotoxin-, glutamate- and drug-induced inflammation and cytotoxicity with emphasis on signal transduction mechanisms
Sammanfattning : Inflammatory cells such as monocytes and glial cells play an important role in the pathogenesis of ischemic- or drug-induced brain or liver injury. Excessive concentrations of glutamate is toxic to neural cells, and triggers a series of transcriptional events beginning with the expression of the immediate early genes like c-fos and c-jun, which in turn affect the expression of other genes necessary for the development of brain injury. LÄS MER
3. TNFalpha expression in monocytes/macrophages
Sammanfattning : The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). LÄS MER
4. On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants
Sammanfattning : Orthopaedic implants enable the restitution of locomotor function and improve the quality of life of many people. However, biomaterial-associated infection may occur due to the propensity of microorganisms to adhere and colonize implant surfaces. LÄS MER
5. Genetic Variations in the NLRP3 Inflammasome : Susceptibility Factor for Chronic Inflammation
Sammanfattning : NLRP3 has been recognized as one of the key components of innate immunity. Upon activation, NLRP3 forms a multiprotein complex called as the ‘inflammasome’ which leads to the activation of pro-inflammatory caspase-1 which subsequently results in the formation of Interleukin (IL)-1β and IL-18. LÄS MER