Sökning: "TGFBR1"

Hittade 2 avhandlingar innehållade ordet TGFBR1.

1. 1. Genetic studies of colorectal cancer

   Författare :Johanna Skoglund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :colorectal cancer; linkage analysis; TGFBR1; case-control study; meta-analysis;

   Sammanfattning : Colorectal cancer is the third most commonly diagnosed cancer worldwide with an incidence rate of over 1 million cases per year. A genetic contribution has been suggested to be involved in around 35% of all colorectal cancer cases. LÄS MER

3. 2. Molecular studies of pancreatic cancer: Characterization of the transforming growth factor beta signaling pathway

   Författare :Tord Jonson; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SMAD4; PCR; FISH; cytogenetics; chromosome; pancreatic cancer; TGFB signaling; cytogenetik; Genetik; Genetics;

   Sammanfattning : In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent breaks close to the centromere of chromosome arm 18q. LÄS MER