Sökning: "TGF-β1"

Visar resultat 1 - 5 av 49 avhandlingar innehållade ordet TGF-β1.

  1. 1. Studies on Cell Injury Induced by Hypoxia-Reoxygenation and Oxidized Low Density Lipoprotein : With Special Reference to the Protectiove Effect of Mixed Tocopherols, Omega-3 Fatty Acids and Transforming Growth Factor-beta1

    Författare :Hongjiang Chen; Tom Saldeen; Christer Sylven; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Tocopherols; fish oil; TGF-β1; NOS; adhesion molecules; MMPs; PKB; MAPK; H-R; Ox-LDL; Myocytes; HCAECs; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : Hypoxia-reoxygenation (H-R) injury is an important clinical phenomenon in patients with coronary artery disease (CAD). Endothelial injury is a critical step in the initiation and progression of atherosclerosis. Therefore, endothelial and cardiomyocyte protection has been considered an effective step in prevention and treatment of CAD. LÄS MER

  3. 2. Effects of sex steroids and tamoxifen on matrix metalloproteinase activity and generation of endostatin in the breast

    Författare :Ulrika W. Nilsson; Charlotta Dabrosin; Lena Claesson-Welsh; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Breast cancer; TGF-β1; Endostatin; Estradiol; Mammary gland; Matrix metalloproteinases; MCF-7; Microdialysis; Nude mice; Tamoxifen; Oncology; Onkologi;

    Sammanfattning : Sex steroids are inevitable in women. However, long-term exposure to sex steroids increases the risk of breast cancer. A complete understanding of sex steroid control of the breast and how it relates to breast cancer risk is still lacking. LÄS MER

  4. 3. Inflammatory responses of gingival fibroblasts in the interaction with the periodontal pathogen Porphyromonas gingivalis

    Författare :Eleonor Palm; Torbjörn Bengtsson; Hazem Khalaf; Gunnel Svensäter; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Porphyromonas gingivalis; fibroblasts; CXCL8; TGF-β1; IL-6; SLPI; IDO; c-JUN; PKC; p38; periodontitis; Biomedicin; Biomedicine;

    Sammanfattning : .... LÄS MER

  5. 4. Dynamic changes in chemotactic and metabolic properties in tumor cells undergoing TGFb1-induced Epithelial-Mesenchymal Transition (EMT)

    Författare :Nikolina Giotopoulou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial-Mesenchymal Transition (EMT) is a process linked to several hallmarks of cancer including metabolic switching, inflammation, and chemotactic properties. Tumor cells that undergo EMT lose epithelial characteristics like cell-cell adhesion and apical basal polarity and gain expression of mesenchymal proteins including intermediate filaments and various cell surface receptors. LÄS MER

  7. 5. Regulatory Effects of TGF-β Superfamily Members on Normal and Neoplastic Thyroid Epithelial Cells

    Författare :Åsa Franzén; Paschalis Sideras; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; activin; BMP; cadherin; carcinoma; cell cycle arrest; dedifferentiation; EGF; growth inhibition; invasion; Smad; TGF-β; thyroid; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Thyroid growth and function is partly regulated by growth factors binding to receptors on the cell surface. In the present thesis, the transforming growth factor-β (TGF-β) superfamily members have been studied for their role in regulation of growth and differentiation of both normal and neoplastic thyroid epithelial cells. LÄS MER