Sökning: "TCR"
Visar resultat 6 - 10 av 173 avhandlingar innehållade ordet TCR.
6. Islet xenotransplantation : An immunological study in the pig-to-mouse model
Sammanfattning : Successful clinical xenotransplantation, i.e., transplantation between species, would eliminate the shortage of donor organs. In order to study the acute cellular rejection reaction following discordant xenogeneic transplantation, an experimental pig-to- mouse islet xenotransplantation model was established. LÄS MER
7. Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes
Sammanfattning : Type 1 diabetes is an autoimmune disorder determined both by genetic and environmental factors. The Non-obese diabetic (NOD) mouse is one of the best animal models of this disease. It spontaneously develops diabetes through a process resembling the human pathogenesis. LÄS MER
8. Tumor-targeted superantigens for experimental immunotherapy of human leukemia/lymphoma
Sammanfattning : Bacterial superantigens (SAgs) have the property of stimulating high proportions of T cells expressing certain TCR Vβ sequences. The SAg first binds with high affinity to HLA class II molecules on the target cell and then stimulates the T cell to produce cytokines and to become cytotoxic. LÄS MER
9. Immune cells in pregnant uterine mucosa : functional properties, cellular composition and tissue organization
Sammanfattning : The pregnant uterus mucosa - decidua - is an "immunologically privileged" site. A semiallogeneic embryo is allowed to survive, develop, and grow while the same tissue implanted outside the uterus will be rejected. The decidua basalis, which participates in the placenta formation, is a tissue rich in lymphoid cells. LÄS MER
10. Regulation of T cell activation and death by the affinity of TCR for peptide/MHC complexes
Sammanfattning : The aim of this study is to investigate the role of the affinity of peptide:MHC/TCR interaction in the regulation of T cell activation, death and repertoire selection. Three aspects pertinent for our understanding of this issue have been analyzed. LÄS MER