Sökning: "TCR"

Visar resultat 21 - 25 av 173 avhandlingar innehållade ordet TCR.

1. 21. Early events in T cell development

   Författare :Karin Leandersson; Malmö Cancerimmunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; pTalpha; gammadelta T cell; alphabeta T cell; development; thymus; thymocyte; serology; transplantation; Immunologi; serologi;

   Sammanfattning : T cells constitute a heterogenous population of lymphocytes. Their unifying property is that they express surface bound antigen-receptors, called T cell receptors (TCRs). The TCR is a heterodimer composed of either TCRalpha and beta chain proteins (alphabeta TCR) or gamma and delta chain proteins (gammadelta TCR). LÄS MER

3. 22. Molecular basis for enhanced T-cell recognition and cross-reactivity

   Författare :Eva Allerbring; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with peptide/MHC complexes occur throughout the lifespan of T cells, from development to activation, with the origin of the peptide varying between self and foreign. LÄS MER

4. 23. Some studies on human aB+ and yd+ T lymphocytes in health and disease

   Författare :Semih Esin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :T cell receptor; Autoimmunity; Mycobacteria; Behcet s disease; Flow cytometry; Proliferation; Intestine; yd T cells; Infection;

   Sammanfattning : T lymphocytes use the T cell receptor (TCR) to specifically recognize antigens. According to the type of TCR heterodimer, T cells can be phenotypically divided into a B+ or yd+ subsets. In many human inflammatory/autoimmune diseases significant expansions of aB+ and yd+ T cells have been described. LÄS MER

5. 24. Studies of T cells in health and disease : receptor usage and cytokine expression

   Författare :Eva Halapi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :T cell receptor; oligoclonal expansion Tumour-infiltrating Iymphocyte; Ovarian carcinoma; Interleukin 10; Multiple Myeloma; Systemic vasculitis; HLD DR0401*CDR3; HIV-I;

   Sammanfattning : T Iymphocytes are crucial components for the initiation and maintenance of an immune response. To identify and characterize different T cells and their antigen specific receptors has important bearing for the understanding of underlying mechanisms in immunopathological processes and also to allow for the design of therapeutic therapies to be used for modulation of immune responses. LÄS MER

7. 25. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

   Författare :Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER