Sökning: "TAK-779"

Hittade 2 avhandlingar innehållade ordet TAK-779.

1. 1. Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage

   Författare :Liselotte Antonsson; Drug Target Discovery; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; evolution; pathogenesis; cerebrospinal fluid; Medicine human and vertebrates ; TAK-779; RANTES; CXCR4; CCR5; coreceptor; GPCR; HIV-1;

   Sammanfattning : The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of infected individuals. LÄS MER

3. 2. Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates

   Författare :Ulf Karlsson; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : HIV-1 infection of CD4+ immune cells requires the assistance of cellular coreceptors. The regulation of these receptors is highly dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in vivo is yet to be established. LÄS MER