Sökning: "T-celler"
Visar resultat 1 - 5 av 76 avhandlingar innehållade ordet T-celler.
1. Chemokine Receptor CCR9: Studies on the Generation and Localization of Gut Tropic Lymphocytes
Sammanfattning : Lymphocytes are important mediators of adaptive immune responses. Naive T lymphocytes circulate in the blood and lymph between different secondary lymphoid organs in search for their specific antigen. LÄS MER
2. Studies on the function of CD4CD25 regulatory T cells: An in vitro approach
Sammanfattning : Immunological self-tolerance is a state of the whole organism where deleterious responses are either avoided or regulated. Breaking of immunological tolerance will lead to autoimmune disease or chronic inflammatory conditions. LÄS MER
3. The ups and downs of T cells The role of costimulatory molecules in the modulation of T cell responses
Sammanfattning : T cell activation requires the combination of antigen in the context of MHC and costimulatory molecules to induce a functional immune response. For our studies, we primarily utilized superantigens (SAg) that bind MHC class II molecules as first signal. LÄS MER
4. Early events in T cell development
Sammanfattning : T cells constitute a heterogenous population of lymphocytes. Their unifying property is that they express surface bound antigen-receptors, called T cell receptors (TCRs). The TCR is a heterodimer composed of either TCRalpha and beta chain proteins (alphabeta TCR) or gamma and delta chain proteins (gammadelta TCR). LÄS MER
5. On the induction and function of Foxp3+ regulatory T cells
Sammanfattning : This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. LÄS MER
