Sökning: "T-antigen"
Visar resultat 6 - 10 av 21 avhandlingar innehållade ordet T-antigen.
6. p53 and neoplastic progression in Barrett's esophagus
Sammanfattning : Barrett's esophagus is a condition in which the normal squamous epithelium is replaced by columnar epithelium as a response to acid reflux. It develops as a complication in 10-20% of patients with gastroesophageal reflux disease. LÄS MER
7. Effects of polyomavirus T antigens on cellular signal transduction pathways
Sammanfattning : The early viral proteins, the tumor (T) antigens, of mouse polyomavirus,stimulate cell growth by interaction with cellular growth regulating proteins.The viral interference with cellular growth regulation may, eventually, alsoresult in effects on cellular apoptosis (programmed cell death) mechanisms. LÄS MER
8. Activity of tumor-antigens in polyomavirus replication
Sammanfattning : Polyomavirus replication needs an active cell environment, and the viral DNA replication is cell cycle regulated. Tumor antigens (T-antigens) of mouse polyomavirus, especially large T-antigen, are necessary for the replication. LÄS MER
9. Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma
Sammanfattning : Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of truncated LT. It is evident that the viral truncated LT and small T antigen (sT) play important roles in MCC tumorigenesis. LÄS MER
10. Dissecting the roles of viral T-antigens in Merkel cell carcinoma
Sammanfattning : Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced DNA damage. The MCPyV T-antigens are major drivers for MCC oncogenesis. LÄS MER