Sökning: "T cells"
Visar resultat 11 - 15 av 2069 avhandlingar innehållade orden T cells.
11. T cells in atherogenesis
Sammanfattning : The work of this thesis aims to answer the following questions: (1) Which role do CD4+ cells play in atherosclerosis? (2) Is the expression of CD4 essential for the athero-protective effect mediated by immunization with oxidized LDL by adjuvant? (3) How does the antigenspecific T cell response to oxidized LDL influence lesion development? (4) Is there a general shift to Th2 responses in severe hypercholesterolemia? and finally (5) Which role does transforming growth factor-B (TGF-B)-signaling in T cells play in atherogenesis? ApoE-/-CD4-/- mice were used to study the effect of CD4 deficiency in atherosclerosis. The development of atherosclerosis was decreased with attenuated inflammation in apoE-/- mice lacking CD4+ cells compared to immunocompetent apoE-/-. LÄS MER
12. The immortalization process of T cells : with focus on the regulation of telomere length and telomerase activity
Sammanfattning : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. LÄS MER
13. Immunity to Rotavirus infection across ages
Sammanfattning : Rotavirus (RV) is a double-stranded RNA virus that mainly affects young children under the age of five years. It is one of the leading causes of dehydrating gastroenteritis. Every year, about 200,000 child deaths occur due to RVinfection. Vaccines exist and are in use worldwide. LÄS MER
14. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy
Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER
15. Potential immunoregulatory role of T and dendritic cells in cancer : Investigations based on transcriptional analysis
Sammanfattning : Cancer is a complex disease with various genetic and epigenetic driving factors. Cancer cells form a favored microenvironment to sustain their uncontrolled behavior leading to abnormal growth. With standard treatment including chemotherapy, relapse risk is high due to the resistance that cancer cells can develop against chemotherapy agents. LÄS MER