Sökning: "Systems biology"

Visar resultat 21 - 25 av 696 avhandlingar innehållade orden Systems biology.

  1. 21. Resistance to neuraminidase inhibitors in influenza A virus isolated from mallards

    Författare :Goran Orozovic; Björn Olsen; Johan Lennerstrand; Sigvard Olofsson; Linnéuniversitetet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; influenza; mallards; neuraminidase; PCR; sequencing; mutation; oseltamivir; zanamivir; resistance; NAI; antivirals; pandemic; Virology; Virologi; Molecular biology; Molekylärbiologi; Bioinformatics; Bioinformatik; Zoonotic Ecology; Zoonotisk ekologi; Virologi; Virology; Biochemistry; Biokemi;

    Sammanfattning : Influenza A virus belongs to the Orothomyxoviridae family of viruses and is one of the most common pathogens that cause infections of the respiratory tract. The aim of this thesis was to investigate if neuraminidase inhibitor (NAI) Tamiflu® (oseltamivir, OC) and Relenza® (zanamivir, ZA) - related resistance mutations exist in the neuraminidase (NA) gene of viruses collected from wild birds. LÄS MER

  2. 22. Multiscale Modeling in Systems Biology : Methods and Perspectives

    Författare :Adrien Coulier; Andreas Hellander; Mark Chaplain; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; computational systems biology; high performance computing; Bayesian inference; stochastic simulation; cell mechanics; Scientific Computing; Beräkningsvetenskap;

    Sammanfattning : In the last decades, mathematical and computational models have become ubiquitous to the field of systems biology. Specifically, the multiscale nature of biological processes makes the design and simulation of such models challenging. LÄS MER

  3. 23. A multivariate approach to computational molecular biology

    Författare :Fredrik Pettersson; Michael Sjöström; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; PLS; PCA; biomarker; Drosophila; SNP; linkage; disequilibrium; bioinformatics; computational; molecular; biology; genomics; microarray; SELDI; proteomics; Bioinformatics; Bioinformatik;

    Sammanfattning : This thesis describes the application of multivariate methods in analyses of genomic DNA sequences, gene expression and protein synthesis, which represent each of the steps in the central dogma of biology. The recent finalisation of large sequencing projects has given us a definable core of genetic data and large-scale methods for the dynamic quantification of gene expression and protein synthesis. LÄS MER

  4. 24. Managing Complex Environmental Risks for Sustainable Development

    Författare :Mikael Karlsson; Karlstads universitet; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURAL SCIENCES; NATURVETENSKAP; Sustainable development; risk assessment; risk management; complexity; trust; scientific uncertainty; hazardous chemicals; genetically modified organisms; reflexive modernization; ecological modernization; environmental policy; polluter pays principle; pr; Miljö- och energisystem; Environmental and Energy Systems; Hållbar utveckling; Biology; Biologi;

    Sammanfattning : The thesis is concerned with the problematic question on how to manage complex environmental risks in a way that promotes sustainable development. While there are some positive signs on progressive and successful environmental policy, environmental change resulting from human activities still causes severe problems and risks worldwide. LÄS MER

  5. 25. Bioinformatic Methods in Metagenomics

    Författare :Johannes Alneberg; Anders F. Andersson; Lars Arvestad; Nicola Segata; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; Bioinformatics; Metagenomics; Microbiome; Binning; Baltic Sea; Bioinformatik; Metagenomik; Mikrobiom; Binning; Östersjön;

    Sammanfattning : Microbial organisms are a vital part of our global ecosystem. Yet, our knowledge of them is still lacking. Direct sequencing of microbial communities, i.e. LÄS MER