Sökning: "Systemic lupus erythematosus SLE"

Visar resultat 1 - 5 av 120 avhandlingar innehållade orden Systemic lupus erythematosus SLE.

  1. 1. Dissecting the Genetic Basis of Systemic Lupus Erythematosus : The Pursuit of Functional Variants

    Författare :Angélica María Delgado Vega; Ulf Gyllensten; Marta E. Alarcon-Riquelme; Jane Worthington; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; SLE; Genetic Mapping; Association Studies; Functional Variants; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Systemisk Lupus Erythematosus; SLE; Genetik; Genetisk Association; Funktionella Varianter; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Lupus Eritematoso Sistémico; LES; Estudios de Asociación Genética; Variantes Funcionales; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Medical Genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease that primarily affects women during the childbearing years. SLE is characterized by the production of autoantibodies against nucleic acids and their interacting proteins. LÄS MER

  2. 2. The Genetics of Systemic Lupus Erythematosus : The Specificity of IRF5 to SLE

    Författare :MV Prasad Linga Reddy; Marta Alarcön Riquelme; Dan Holmberg; Uppsala universitet; []
    Nyckelord :Molecular genetics; Systemic lupus erythematosus; Interferon regulatory factor 5; Transmission-Disequilibrium Test; Family-based association test; Linkage Disequilibrium; Hardy-Weinberg equilibrium; Genetik;

    Sammanfattning : The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, etc. LÄS MER

  3. 3. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE

    Författare :Anna-Karin B. Lindqvist; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Systemic lupus erythematosus; complex diseases; genetic susceptibility; linkage analysis; genome scan; candidate gene; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. LÄS MER

  4. 4. Genetic Risk Factors for Systemic Lupus Erythematosus : From Candidate Genes to Functional Variants

    Författare :Anna-Karin Abelson; Marta Alarcón-Riquelme; Holger Luthman; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; SLE; association study; complex disease; genetic; Medical genetics; Medicinsk genetik;

    Sammanfattning : The aim of this thesis has been to identify genetic variants that increase the susceptibility for Systemic Lupus Erythematosus (SLE), an autoimmune disease caused by a complex interplay between various genetic and environmental factors. Five different candidate genes were selected through different strategies, and were analysed for association with SLE in an attempt to distinguish some of the underlying mechanisms of this disease. LÄS MER

  5. 5. Imaging findings and neurocognitive function inpatients with Systemic Lupus Erythematosus (SLE)

    Författare :Jessika Nystedt; Lund Diagnostisk radiologi; []
    Nyckelord :Systemic lupus erythematosus SLE ; Neuroimaging; Functional magnetic resonance imaging; Diffusion tensor imaging DTI ; cognitive function.; neuropsychiatric systemic lupus erythematosus; Magnetic resonance imaging MRI ; resting state;

    Sammanfattning : .... LÄS MER