Sökning: "Synaptic Transmission"

Visar resultat 16 - 20 av 75 avhandlingar innehållade orden Synaptic Transmission.

  1. 16. Investigation of the intercellular transmission of α-synuclein, amyloid-β and TDP-43

    Författare :Christopher Sackmann; Martin Hallbeck; Emelie Severinsson; Poul Henning Jensen; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α-synuclein; amyloid-β; TDP-43; cell to cell transmission;

    Sammanfattning : Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are disorders characterized by the progressive deposition of proteinaceous inclusions throughout the brain in a predictable manner. Each disease is described by the involvement of different misfolded and aggregated proteins (AD, amyloid-β and tau; PD, α-synuclein; ALS and FTLD, TDP-43) that spread between anatomically connected brain regions, causing cell death in previously healthy regions. LÄS MER

  3. 17. Plasticity of the developing glutamate synapse in the hippocampus

    Författare :Therése Abrahamsson; Göteborgs universitet; []
    Nyckelord :synaptic plasticity; long-term potentiation; short-term potentiation; silent synapse; development; hippocampus; glutamate;

    Sammanfattning : Synapses are highly plastic, i.e. they have the ability to change their signaling strength both in the short- and long-term (e.g. LÄS MER

  4. 18. Mediators of synaptic activity in anxiety- and depression-related behaviors

    Författare :Carly Kiselycznyk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously rather than from an understanding of the biological mechanisms underlying depression. LÄS MER

  5. 19. The role of multifunctional scaffolding proteins in the synaptic vesicle cycle

    Författare :Wei Jiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Fast synaptic transmission occurs at specialized junctions between neurons referred to as chemical synapses. Action potentials induce an influx of calcium ions into presynaptic terminals, which contain neurotransmitter-filled synaptic vesicles (SVs), triggering fusion of the vesicles with the plasma membrane and resulting in the release of neurotransmitters. LÄS MER

  7. 20. On the role of metabotropic glutamate receptors in motor control : analysis of synaptic, cellular and network properties

    Författare :Patrik Krieger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :calcium channels; lamprey; locomotion; metabotropic glutamate receptors; neuronal network; spinal cord; synaptic transmission;

    Sammanfattning : The organization of neurons into neuronal networks is a basic feature of the central nervous system. An understanding of the function of neuronal networks requires knowledge on both synaptic connectivity and cellular properties. LÄS MER