Sökning: "Suspension bead array"

Visar resultat 6 - 10 av 17 avhandlingar innehållade orden Suspension bead array.

  1. 6. Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum

    Författare :Kimi Drobin; Jochen M. Schwenk; Peter Nilsson; Ulrika Qundos; Angela Silveira; Maria Pernemalm; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; affinity proteomics; immunoassay; antibody microarray; suspension bead array; protein profiling; plasma; serum; biomarker discovery; osteoporosis; inflammatory bowel disease; Crohn s disease; ulcerative colitis; Medical Technology; Medicinsk teknologi;

    Sammanfattning : Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. LÄS MER

  3. 7. Affinity assays for profiling disease-associated proteins in human plasma

    Författare :Sanna Byström; Jochen M. Schwenk; Claudia Fredolini; Peter Nilsson; Jennifer Van Eyk; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; affinity proteomics; immunoassay; antibody microarray; suspension bead array; protein profiling; immuno-capture; plasma; serum; cerebrospinal fluid; biomarker discovery; multiple sclerosis; malignant melanoma; mammographic breast density; Bioteknologi; Biotechnology;

    Sammanfattning : Affinity-based proteomics offers opportunities for the discovery and validation of disease-associated proteins in human body fluids. This thesis describes the use of antibody-based immunoassays for multiplexed analysis of proteins in human plasma, serum and cerebrospinal fluid (CSF). LÄS MER

  4. 8. Multiplexed antibody-based protein profiling in the pursuit of CSF biomarkers for neurodegenerative diseases

    Författare :Sofia Bergström; Peter Nilsson; Anna Månberg; Markus Otto; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Protein profiling; suspension bead array; cerebrospinal fluid; biomarker discovery; proteomics; Bioteknologi; Biotechnology;

    Sammanfattning : There is a desire for a transition from generic treatments designed for the average patient, towards more individual-based precision medicine. An increased knowledge about disease pathophysiology on a molecular level would be beneficial for this transition. LÄS MER

  5. 9. On the application and validation of multiplexed affinity assays

    Författare :Tea Dodig-Crnković; Jochen M. Schwenk; Mun-Gwan Hong; Peter Nilsson; Norman Leigh Anderson; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity proteomics; Antibody; Autoantibody; Multiplexed assays; Protein microarray; Plasma proteins; Suspension bead array; Bioteknologi; Biotechnology;

    Sammanfattning : Proteins are essential macromolecules that carry out complex functions in human cells, tissues, and organs. They regulate a diverse set of biological processes and protect against pathogens. However, dysregulation or malformation of proteins can cause disease. LÄS MER

  7. 10. Protein based approaches to understand and prevent contagious bovine pleuropneumonia

    Författare :Carl Hamsten; Anja Persson; Joachim Frey; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; CBPP; Mycoplasma mycoides subsp. mycoides small colony type; humoral immune responses; recombinant surface proteins; ELISA; subunit vaccine; suspension bead array; Bioengineering; Bioteknik;

    Sammanfattning : Contagious bovine pleuropneumonia (CBPP) is a severe infectious disease caused by Mycoplasma mycoides subsp. mycoides small colony type (M. mycoides SC) and is a vast problem in Africa. LÄS MER