Sökning: "Surface plasmon resonance"

Visar resultat 6 - 10 av 185 avhandlingar innehållade orden Surface plasmon resonance.

1. 6. Towards specific quantification of exosomes using surface-based sensing

   Författare :Deborah Rupert; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; label-free; surface plasmon resonance.; exosome; binding rate; antibody; concentration; nanoparticle tracking analysis; quantification; liposome; cluster of differentiation 63 CD63 ; diffusion; specific detection; mass transport limited conditions; extracellular vesicles; surface-based biosensor;

   Sammanfattning : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. LÄS MER

3. 7. Physical characterization of exosomes and other extracellular vesicles using surface-based sensing

   Författare :Deborah Rupert; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nanoparticle tracking analysis; exosomes; scattering; surface-based biosensing; optical density; cluster of differentiation 63 CD63 ; liposomes; label-free; fluorescence; surface plasmon resonance; Extracellular vesicles; specificity; antibody; lipid content; single particle; quantification; size distribution; optical waveguide microscopy;

   Sammanfattning : Extracellular vesicles (EVs) are hundred of nanometer sized particles secreted by almost all cell types. Exosomes are one type of EVs today intensively investigated due to the increased evidence suggesting that they play important roles as communicating vehicles in a broad range of physiological processes, pathological conditions and disease diagnostics. LÄS MER

4. 8. Interactions Between Localized Surface Plasmons and Molecular Resonances

   Författare :Gülis Zengin; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; single particles; J-aggregates; Rhodamine 6G; Localized surface plasmon resonance; strong coupling; surface-enhanced absorption;

   Sammanfattning : Molecular plasmonics is the study of interactions between plasmonic nanostructures and molecules. It has been basis for fundamental understanding of light-matter interactions and development of many technological applications, such as biological and chemical sensing, plasmon-enhanced spectroscopies, optical switches, and plasmon-enhanced energy harvesting. LÄS MER

5. 9. Mechanistic and morphological studies of Aβ amyloid formation using surface plasmon resonance

   Författare :Md Tohidul Islam; Anders Olofsson; Ludmilla Morozova-Roche; Vytautas Smirnovas; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; medicinal chemistry; läkemedelskemi; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and apart from the individual suffering AD also causes a large economic burden for society. AD is associated with progressive neurodegeneration and atrophy of the brain. LÄS MER

7. 10. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

   Författare :Helena Nordström; Helena Danielson; Gregg Siegal; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fragment based drug discovery; SPR biosensor; matrix metalloproteinase-12; HIV-1 protease; resistance;

   Sammanfattning : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. LÄS MER