Sökning: "Sun Xiaojiao"

Hittade 1 avhandling innehållade orden Sun Xiaojiao.

1. 1. High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation

   Författare :Xiaojiao Sun; Lars Baltzer; Thomas Norberg; Ulf Nilsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide; conjugates; D-dimer; myeloperoxidase; chitinase;

   Sammanfattning : This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. LÄS MER