Sökning: "Substituents"
Visar resultat 1 - 5 av 146 avhandlingar innehållade ordet Substituents.
1. Enzyme Hydrolysis of Cellulose Derivatives. Active Site Studies and Polymer Characterisation
Sammanfattning : Soluble derivatives of cellulose have become increasingly important in industrial products e.g. in pharmaceutical applications and in technical dispersions. The polymer characteristics of modified celluloses are to a high degree determined by the substituent distribution along the polymeric backbone. LÄS MER
2. New Arylation Strategies Based on Organomain Group Reactivity
Sammanfattning : The work in this thesis describes the development of new heteroarylation methodology based on transition metal-catalysed C-H functionalisation and the properties of organomain group compounds. The underlying reaction mechanisms and reactivity patterns of the (hetero)arene substrates are also investigated. LÄS MER
3. Small-Molecule Galectin Inhibitors - On Tweezers and Talosides
Sammanfattning : Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. LÄS MER
4. Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-1
Sammanfattning : This thesis describes the synthesis of molecules designed for inhibition of two aspartic proteases, viral HIV-1 PR and human BACE-1. It also reports on the structure activity relationships of the targeted enzyme inhibitors. It is estimated that currently 33 million people are infected with HIV, the causative agent of AIDS. LÄS MER
5. Synthesis and chemical modification of some carbohydrates containing amino groups
Sammanfattning : The alkylation with alkyl trifluoromethanesulfonates of hydroxyl groups in carbohydrates, containing base- or acid-labile substituents, has been examined. The reagent simultaneously transforms acetamindo groups to N-methylamino groups. Synthesis and nitrous acid deamination of methyl 4-amino-4-deoxy-β-L-arabinopyranoside has been performed. LÄS MER