Sökning: "Subiculum"

Hittade 4 avhandlingar innehållade ordet Subiculum.

  1. 1. Bridging the gap in translational epilepsy research - A patient brain tissue platform for validating animal data

    Författare :Jenny Wickham; Epilepsicentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; patch clamp technique; human tissue; Optogenetics; Dentate gyrus; Subiculum; Hippocampus; in vitro;

    Sammanfattning : .... LÄS MER

  3. 2. Cyclic nucleotide signalling in Alzheimer's disease postmortem brain

    Författare :Willy Lokwa Bonkale; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this study was to determine the nature and significance of altered guanylyl cyclase (GC) and adenylyl cyclase (AC) signalling in Alzheimer's disease (AD) postmortem brain. Paper I describes a study of particulate and soluble GC activities in postmortem temporal cortex from a series of AD and matched control subjects. LÄS MER

  4. 3. Alzheimer's disease : towards a multifaceted approach in neuropathological diagnosis

    Författare :Nenad Bogdanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; CERAD; neurofibrillary tangles. neuritic plaques; apoE. synaptic proteins; rab3a; synaptophysin; synaptotagmin; GAP-43; neurogranin; neuronal degeneration; optical disector 1998;

    Sammanfattning : The main aim of this study has been to investigate potential neuropathological features which may play an important role in understanding the cognitive dysfunction and in making the final diagnosis of Alzheimer's disease (AD). To establish a reliable diagnosis of AD, standardisation and uniformity of the diagnostic protocols must become mandatory. LÄS MER

  5. 4. Galanin receptor subtypes in rodent models of mood disorders

    Författare :Tara Wardi-Le Maitre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-HT1A receptor; galanin; galanin receptor 2 overexpressing mice; locus coeruleus; dorsal raphe; depression-like behavior; forced swim test;

    Sammanfattning : Major depressive disorder (MDD) is a serious mental illness, with a complex etiology. It is a multifactorial disorder caused by a combination of genetic, environmental and epigenetic factors. Exposure to stressful life events seems to be a common, contributing cause of morbidity. LÄS MER