Sökning: "Strukturbiologi"

Visar resultat 21 - 25 av 264 avhandlingar innehållade ordet Strukturbiologi.

  1. 21. Major Intrinsic Proteins - Structure, function, interactions

    Författare :ANDREAS KIRSCHT; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aquaporin; membrane proteins; crystallography; stopped-flow; molecular dynamics; structure modeling;

    Sammanfattning : Major intrinsic proteins, also referred to as aquaporins (AQPs) are localized in membranes of all domains of life to increase the permeability to water or other small, polar molecules. Several monophyletic groups can be discerned in this large and divergent protein superfamily. LÄS MER

  3. 22. The Design and Structure Prediction of Protein Oligomers

    Författare :Robert Lizatovic; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virus capsids; coiled coils; molecular replacement; symmetry; Rosetta; protein design; structure prediction;

    Sammanfattning : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. LÄS MER

  4. 23. Protein-Protein Interactions in Human Aquaporin Regulation

    Författare :Jennifer Virginia Roche; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; Human Aquaporins; water channels; Protein-protein interaction; Regulation; AQP2; AQP0; LIP5; CaM;

    Sammanfattning : Water is an essential compoment of every living orgamism and forms a major part of the human body. Regulated water transport is crucial for proper cell functioning and body homeostasis. LÄS MER

  5. 24. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

    Författare :Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

    Sammanfattning : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. LÄS MER

  7. 25. Painfully Energetic : A tale of two proteins potentially connected

    Författare :Eva Sperling; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complex I; Mrp-antiporter; Membrane bound hydrogenases; TRP ion channels; TRPA1; thermosensation; chemosensation; 23Na-NMR;

    Sammanfattning : NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. LÄS MER