Sökning: "Strukturbiologi"

Visar resultat 16 - 20 av 264 avhandlingar innehållade ordet Strukturbiologi.

  1. 16. Membrane Protein Tailoring and Structural Studies of Leukotriene C4 Synthase

    Författare :Daniel Martinez Molina; Pär Nordlund; Robert M. Stroud; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; random mutagenesis; detergent screening; Leukotriene C₄ synthase; IMAC; Structural biology; Strukturbiologi; Biochemistry; biokemi;

    Sammanfattning : Despite a dramatic increase in the number of proteins that have been structurally characterized in recent years, there are still less than 200 unique structures of membrane proteins known today. This is only 1% of the total number of unique protein structures found in structural databases worldwide. LÄS MER

  3. 17. Structural Studies of Flexible Biomolecules and a DNA-binding Protein

    Författare :Tariq Massad; Pål Stenmark; Cheryl Arrowsmith; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Maximum entropy; motilin; DNA-binding proteins; Karplus equation; disaccaride; direct repeats; Structural biology; Strukturbiologi; Biophysics; biofysik;

    Sammanfattning : The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. LÄS MER

  4. 18. Nanoscopic adventures : unraveling macromolecular complexes in infectious diseases via integrative structural biology

    Författare :Kai Patric Ehrenbolger; Ronnie Berntsson; Felipe Cava; Jonas Barandun; David Drew; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Infectious diseases; E. faecalis; Microsporidia; Ribosome; Proteasome; Polar Tube; Structural Biology; Single particle Cryo-Electron Microscopy;

    Sammanfattning : This thesis focuses on understanding the underlying molecular mechanisms of infectious diseases, which claim nearly 9 million lives annually. The research centers on critical analysis of pathogen mechanisms and drug resistance. I have mainly focused on two clades of pathogens: Enterococcus faecalis and microsporidia. E. LÄS MER

  5. 19. Exploring Unorthodox Aquaporins : Characterization of NbXIPs & AtNIPs

    Författare :Henry Ampah-Korsah; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aquaporins; XIPs; NIPs; Phosphorylation; Pichia pastoris; Overexpression; boric acid; membrane proteins;

    Sammanfattning : AbstractAquaporins are membrane integral proteins that facilitate the transport of waterand/or other small neutral molecules across biological membranes in cells in allforms of life. Among the subfamilies of aquaporins in higher plants, the X IntrinsicProteins (XIPs) are the most recently discovered subfamily and the leastcharacterized. LÄS MER

  7. 20. To reduce a ribonucleotide – Radical solutions in enzymology in form and function

    Författare :Oskar Aurelius; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; X-ray crystallography; Small-angle X-ray scattering; nucleotide metabolism; protein biophysics; metalloproteins; anaerobic enzymology;

    Sammanfattning : It has been more than 50 years since the enzyme system ribonucleotide reductase (RNR), catalysing the reduction of ribonucleotides to deoxyribonucleotides, was first discovered. RNR was also the first time that radical chemistry was revealed in an enzyme. LÄS MER