Sökning: "Structure-Function"

Visar resultat 16 - 20 av 181 avhandlingar innehållade ordet Structure-Function.

  1. 16. Structure-Function Studies of Enzymes from Ribose Metabolism

    Författare :C. Evalena Andersson; Sherry Mowbray; Phil Evans; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; activation; isomerase; kinase; potassium; product inhibition; ribose; ribose 5-phosphate; x-ray crystallography; enzyme kinetics; fluorescence spectroscopy; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids and cofactors. LÄS MER

  3. 17. Expression and structure-function characterisation of herpesviral proteins

    Författare :Sue-Li Dahlroth; Pär Nordlund; Darren Hart; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein production; Herpesvirus; SOX; E. coli; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : In order to determine and study a protein structure, large amounts of it is needed. The easiest way to obtain a protein is to recombinantly overexpress it in the well-studied bacterium Escherichia coli. However, this expression host has one major disadvantage, overexpressed proteins might not be folded or be insoluble. LÄS MER

  4. 18. Structure-function studies of glutaredoxins and related oxidoreductases

    Författare :Tobias Elgán; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thiol-disulfide oxidoreductase; thioredoxin; Trx; glutaredoxin; Grx; protein disulfide oxidoreductase; PDO; -C-X-X-C-; specificity; conformational stability; ligandinduced stability; CD spectroscopy; redox potential;

    Sammanfattning : The members of the ubiquitous group of thiol-disulfide oxidoreductases are characterized by a conserved tertiary structure, the thioredoxin (Trx) fold, and by having a consensus -C-X-X-C- active site sequence motif. By utilizing the active site cysteines, these proteins participate in redox reactions by catalyzing reversible disulfide oxidation and reduction. LÄS MER

  5. 19. Modulating the structure-function relationship of mucin materials

    Författare :Kun Jiang; Thomas Crouzier; Qi Zhou; Mark Tibbitt; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioteknologi; Biotechnology;

    Sammanfattning : Mucus covers the epithelium surfaces playing a key role in the barrier, hydration, lubrication and bioactivity functions for the human body, and mucins are the fundamental components of mucus which provide such functions. However, many details in how these functions are related to the many structural features of mucins are still unknown. LÄS MER

  7. 20. Conserved structure-function relationships in the mediator complex

    Författare :Tomas Linder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Transcription; Mediator; yeast;

    Sammanfattning : The Mediator complex is an essential multiprotein coregulator of RNA polymerase II (pol II)- dependent transcription in fungi and metazoans. Mediator interacts directly with both pol II and sequence-specific transcriptional regulators and thus acting as a bridge between the two. LÄS MER