Sökning: "Stromelysin"

Hittade 5 avhandlingar innehållade ordet Stromelysin.

  1. 1. Legg-Calvé-Perthes´ disease. Synovitis, cartilage, remodeling

    Författare :Göran Eckerwall; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Stromelysin; Sonography; Remodeling; Proteoglycan; Pressure; Osteotomy; MRI; MR imaging; Metaphysis; Legg-Calvé-Perthes; Histology; Hip; Arthrography; Child; Synovitis; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : This thesis evaluates and correlates the findings in a series of children with Legg-Calvé-Perthes´ Disease at the Departments of Orthopedics, University Hospitals in Lund, Sweden and Odense, Denmark during 1984-1993. It focuses on the importance of synovitis and its effect on the cartilage, on the shape of the femoral head in the early phases of LCPD and on femoral head remodeling after proximal femoral varus derotation osteotomy. LÄS MER

  2. 2. Positive and negative angiogenic factors in patients with malignant disease

    Författare :Christina Linder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :angiogenesis; neovascularization; microvessel density; VEGF; bFGF; stromelysin-3;

    Sammanfattning : In this thesis, the levels of positive and negative angiogenic factors were studied in tissue, serum and urine from patients with malignant disease. The angiogenic factors VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) were studied in breast carcinomas. LÄS MER

  3. 3. Studies on basal cell carcinoma with emphasis on the role of the human homologue of the Drosophila patched gene

    Författare :Anne Birgitte Undén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Basal cell carcinoma BCC ; carcinogenesis; in situ hybridization; linkageanalysis; gene; mutation; PCR; p53; PTCH; SHH; skin; SSCP; stromelysin 3 ST3 ; trichoepithelioma TE ; UVR.;

    Sammanfattning : Basal cell cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. Ultraviolet radiation (WR) is presumed to be the predominant environmental factor. LÄS MER

  4. 4. Injury-induced activation of vascular smooth muscle cells. Role of specific gene expression and intracellular signalling pathways

    Författare :Cecilia Lövdahl; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metalloproteinase; extracellular matrix; ERK1 2 signalling; migration; proliferation; injury; vessel wall; smooth muscle cell; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Migration and proliferation of smooth muscle cells (SMC) are important events in the development of atherosclerosis and restenosis following angioplastic surgery. It is important to gain further knowledge about the mechanisms regulating SMC form and function in order to understand the underlying disease process. LÄS MER

  5. 5. Theoretical Modeling of Enzyme Catalysis with Focus on Radical Chemistry

    Författare :Vladimir Pelmenschikov; Per E. M. Siegbahn; Tim Clark; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; density functional theory; enzyme catalysis; radical chemistry; zinc-containing peptidase; methyl-coenzyme M reductase; ribonucleotide reductase; superoxide dismutase; Quantum chemistry; Kvantkemi;

    Sammanfattning : Hybrid density functional theory (DFT) B3LYP method is applied to study the four diverse enzyme systems: zinc-containing peptidases (thermolysin and stromelysin), methyl-coenzyme M reductase, ribonucleotide reductases (classes I and III), and superoxide dismutases (Cu,Zn- and Ni-dependent enzymes). Powerfull tools of modern quantum chemistry are used to address the questions of biological pathways at their molecular level, proposing a novel mechanism for methane production by methyl-coenzyme M reductase and providing additional insights into hydrolysis by zinc peptidases, substrate conversion by ribonucleotide reductases, and biological superoxide dismutation. LÄS MER