Sökning: "Striatal adenosine A2A receptors"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Striatal adenosine A2A receptors.

1. 1. Striatal adenosine A2A receptors

   Författare :Per Svenningsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :caffeine; adenosine; A2A receptors; dopamine receptors; striatum; basal ganglia; immediate early genes; c-fos; NGFI-A; DARPP-32; in situ hybridization;

   Sammanfattning : The nucleoside adenosine exerts a modulatory action in the central nervous system by activating G-protein coupled receptors. Four such receptors are cloned and pharmacologically characterized: A1, A2A, A2B and A3. Caffeine, the most widely consumed psychostimulant, acts as an adenosine receptor antagonist predominantly on the first two. LÄS MER

3. 2. Adenosine A2A receptors : characterization, localization, G protein coupling and interactions with dopamine D2 receptors

   Författare :Björn Kull; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine receptors; receptor-receptor interactions; G proteins; species differences;

   Sammanfattning : Adenosine not only has a role in cellular energy metabolism but is recognized as an intercellular messenger with an important function in physiology and pathophysiology. It exerts its effects via a family of G protein coupled receptors of which four members have been cloned from several species: A, A2A, A2B and A3. LÄS MER

4. 3. Physiology and pathophysiology of central adenosine A1 and A2A receptors

   Författare :Linda Halldner Henriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine; A1 receptor; A2A receptor; knock-out mouse; in situ hybridization; receptor autoradiography; sleep; hypoxia-ischemia; behavior; motor activity; caffeine; tolerance;

   Sammanfattning : The aim of this thesis was to further investigate the individual roles of central adenosine A1 and A2A receptors in the physiological and pathophysiological effects of adenosine. In addition, the characteristics of different adenosine receptor ligands were studied. LÄS MER

5. 4. Modeling Biochemical Network Involved in Striatal Dopamine Signaling

   Författare :Anu G. Nair; Jeanette Hellgren Kotaleski; Omar Gutierrez Arenas; Upinder Singh Bhalla; Jakob Kisbye Dreyer; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine signaling; Striatum; Reward learning; Acetylcholine; Mass-action modeling; FRET biosensor; Adenosine; Eligibility trace; Computer Science; Datalogi;

   Sammanfattning : In this thesis, I studied the molecular integration of reward-learning related neuromodulatory inputs by striatal medium-sized projection neurons (MSNs) using mass-action kinetic modeling.It is known that, in reward learning, an unexpected reward results in transient elevation in dopamine (peak) whereas omission of an expected reward leads to transient dopamine decrease (dip). LÄS MER

7. 5. Regulation by glutamate- and adenosine-receptors of dopamine and acetylcholine release from rat striatal slices

   Författare :Shaoyu Jin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :striatum; dopamine; acetylcholine; adenosine receptors; glutamatereceptors. ISBN 91-628-2599-2;

   Sammanfattning : The striatum, which is critically involved in sensory motor integration, receives an excitatory glutamatergic input from the cerebral cortex and the thalamus. The effects of the glutamatergic stimulation are modulated by dopamine (DA) released from a prominent dopaminergic input, acetylcholine (ACh) released from cholinergic interneurons and by the ubiquitous neuromodulator adenosine. LÄS MER