Sökning: "Sterol"
Visar resultat 16 - 20 av 52 avhandlingar innehållade ordet Sterol.
16. Studies on a novel oxidative mechanism for elimination of extrahepatic cellular cholesterol
Sammanfattning : Recently, a new oxidative mechanism for elimination of cholesterol from extrahepatic cells by sterol 27-hydroxylase was described. This mechanism involves conversion of cholesterol into 27-hydroxycholesterol and cholestenoic acid. LÄS MER
17. Characterization of peroxisome proliferator-activated receptor alpha (PPARa) regulated acyl-CoA thioesterases involved in lipid metabolism
Sammanfattning : The peroxisome proliferator-activated receptor alpha (PPARalpha) is a key nuclear receptor in the control of lipid metabolism. Target genes for PPARalpha include many enzymes involved in the oxidation of fatty acids in mitochondria and peroxisomes. LÄS MER
18. Global Regulation of Snf1 in Saccharomyces cerevisiae: A case study of experimental systems biology
Sammanfattning : Cells commonly face environmental changes and have evolved various regulatory mechanisms to adjust their metabolism accordingly. One such key regulator in S. cerevisiae is the Snf1 kinase, which belongs to the conserved AMP-activated protein kinase (AMPK) family in all eukaryotes. LÄS MER
19. Studies on the effects of thyroid hormone on cholesterol and lipoprotein metabolism
Sammanfattning : Elevated plasma lipids, particularly cholesterol within low density lipoproteins, is an important risk factor for developing atherosclerosis which can cause angina pectoris, myocardial infarction, and stroke. Thyroid hormone (TH) has a strong influence on lipid metabolism and the aim of this thesis was to gain more insight into how TH modulates cholesterol and lipoprotein metabolism. LÄS MER
20. Cholesterol turnover in acute myelogenous leukemia with special emphasis on regulation of low density lipoprotein receptor expression in leukemic cells
Sammanfattning : Cellular cholesterol requirements are met by receptor mediated uptake of cholesterol in low density lipoprotein (LDL) particles and/or by endogenous synthesis, the rate limiting enzyme in the synthesis pathway being 3-hydroxy-3-methylglutary coenzyme A (HMG-CoA) reductase. Expressions of both the LDL receptor and HMG-CoA reductase genes are normally under end product repression by cellular cholesterol. LÄS MER