Sökning: "Steroid resistance"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden Steroid resistance.

  1. 1. Glucocorticosteroid therapy and steroid resistance in inflammatory bowel disease

    Författare :Lars Flood; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ulcerative colitis; Crohn s disease; Steroid resistance; Glucocorticoid receptor; Nuclear Factor kappaB; Activator Protein 1; Adrenocorticotropin stimulation test; Metallothionein; Rofleponide;

    Sammanfattning : Ulcerative colitis (UC) and Crohn's disease (CD) are diseases of unknown aetiology often referred to as inflammatory bowel diseases (IBD). Glucocorticosteroids (GCS) have been used since the 1950's to treat acute attacks of these diseases. LÄS MER

  3. 2. Metabolic and ovarian consequences of perinatal sex steroid programming

    Författare :Camilla Alexanderson; Göteborgs universitet; []
    Nyckelord :programming; sex steroids; insulin resistance; skeletal muscle; adipose tissue; ovary;

    Sammanfattning : Endocrine and metabolic disturbances in adulthood may stem from insults such as nutritional and hormonal alterations that occur at critical periods in pre- or postnatal life – a process known as programming. This means that suboptimal conditions in utero and early life may contribute to adult reproductive and metabolic impairments such as type 2 diabetes, insulin resistance, and dyslipidemia. LÄS MER

  4. 3. The hypertension-prone man: A study on the pathogenesis of hypertension with regard to insulin sensitivity

    Författare :Tomas Endre; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; sex steroid hormones; sodium retention; glycogen synthase; fibrinolysis; physical fitness; blood flow; insulin resistance; muscle fibres; Kardiovaskulära systemet;

    Sammanfattning : Hypertensive individuals, even non-obese, have been shown to be resistant to the insulin-mediated glucose uptake in peripheral tissues {mainly skeletal muscle}. The aim of this study was to investigate hypothetical pathophysiological mechanisms for the development of hypertension with regard to insulin sensitivity in normotensive men with a family history of hypertension (RELs) as compared to men with no such family history (CONs). LÄS MER

  5. 4. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    Författare :Emma Jernberg; Pernilla Wikström; Jack Schalken; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

  7. 5. Novel mechanisms of glucocorticoid-induced insulin resistance in human adipose tissue

    Författare :Cherno Omar Sidibeh; Jan Eriksson; Maria João Pereira; Anna Krook; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid receptor type 1 fkbp51 dexamethasone type 2 diabetes adipocytes; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The global prevalence of obesity and type 2 diabetes (T2D) is increasing. From a public health perspective, it is therefore of interest to identify common underlying mechanisms of these comorbidities. Glucocorticoids are steroid hormones that are important in stress regulation in mammals. LÄS MER