Sökning: "Steroid receptors"
Visar resultat 11 - 15 av 92 avhandlingar innehållade orden Steroid receptors.
11. Androgen receptors and endocrine disrupting substances
Sammanfattning : Throughout the animal kingdom, organisms are dependent on substances such as steroid hormones to help them maintain internal balances. Examples of important tasks that are under regulation of steroid hormones are somatic and gonadal development, sexual performance and behavior (both social and sexual) as well as sex differentiation. LÄS MER
12. Steroid metabolism in human reproductive organs
Sammanfattning : Androgens are involved in the development of prostate cancer. Both UGT2B17 and CYP7B1 are involved in the metabolism of androgens and are highly abundant in the prostate. Deletion of the UGT2B17 gene is associated with low or undetectable urinary testosterone levels. LÄS MER
13. Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas
Sammanfattning : Uterine fibroids, or leiomyomas, are the most common benign tumors in the female genital tract.They represent a major cause of gynaecologic morbidity. The etiology of these tumors is largely unknown but the levels of estrogen (E) and progesterone (P) are considered to be the major determinants for fibroid growth. LÄS MER
14. Sex steroid effects on normal breast tissue
Sammanfattning : In Sweden, it is estimated that about one million women are treated with estrogen/progestogen for contraception and hormone replacement therapy (HRT). The possibility of an increased cancer risk in target organs has been vividly discussed for many years. LÄS MER
15. Imaging brain aromatase by using PET : A way to study anabolic steroid abuse
Sammanfattning : Aromatase is an enzyme that facilitates the conversion of androgens to estrogens and may play a role in mood and mental status. The main theme of this thesis is the imaging of brain aromatase by use of the PET technique. The PET tracer for aromatase, 11C-labeled vorozole (VOZ) was developed and evaluated by with in vitro and in vivo methods. LÄS MER